Hypothesis: in COPD, a pound of cure may be better than an ounce of prevention

Rennard, Stephen I.; Vestbo, Jørgen

doi:10.1136/thx.2010.151498

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Currently available drug treatments may reduce exacerbation frequency and improve symptoms but significant effects on mortality and long-term decline in lung function have been difficult to demonstrate even in large clinical trials 1 2. Thus, even though active case finding by spirometry is recommended (at least in the UK) and is probably beneficial for symptom and exacerbation management, there is only minimal evidence that pharmacological intervention at any severity of airflow obstruction improves long-term mortality and lung health compared with smoking cessation strategies or, if appropriate, environmental pollution prevention programmes.…”

Section: Introductionmentioning

confidence: 99%

Prospects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational review

Steiner

Roubenoff

Tal‐Singer

et al. 2012

Thorax

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Skeletal muscle dysfunction is a prevalent and clinically important systemic manifestation of chronic obstructive pulmonary disease (COPD) that predicts morbidity and mortality. Skeletal muscle retains its plasticity in response to anabolic stimuli such as exercise in COPD and is therefore a promising target for novel pharmacological therapies aimed at reducing disability and healthcare utilisation and improving mortality. In this article, we outline the steps the academic and pharmaceutical communities need to undertake for such therapeutic advances to be realised.

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Section: Introductionmentioning

confidence: 99%

Prospects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational review

Steiner

Roubenoff

Tal‐Singer

et al. 2012

Thorax

View full text Add to dashboard Cite

show abstract

“…Rennard and Vestbo have sounded a ringing call to arms ( see page ) 1. Instead of trying to make minor improvements in the rate of decline of spirometry in patients with chronic obstructive pulmonary disease (COPD), they call for an all out effort to find a cure.…”

mentioning

confidence: 99%