Hypothesis on the Pathogenesis of Idiopathic Scoliosis

Scoliogeny of adolescent idiopathic scoliosis: inviting contributions for a discussion based on evidence and theoretical interpretations aiming ultimately to prevention or aetiological treatment

“…The application of 3-D biomechanical methods to the trunk [15], simulation by finite element analysis [16], and biomechanical evaluation of the vicious circle hypothesis [17] are all important developments. While a neurobiological [10] and neuromuscular [18] basis for AIS scoliogeny is supported by increasing evidence, systemic metabolic abnormalities have been revealed [19-21] suggesting whole organism involvement [22] and leading to a blood test for idiopathic scoliosis [23]. …”