2019
DOI: 10.1016/j.mehy.2018.10.011
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Hypothesis related to the regulation of inducible nitric oxide synthase during carotid endarterectomy

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Cited by 4 publications
(2 citation statements)
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“…ROS plays an essential role in regulating endothelial function and vascular tone [4] in promoting systemic inflammation, endothelial dysfunction, and vascular remodeling [2,4]. Additionally, superoxide anion (O 2 -) interacts with nitric oxide (NO), producing highly toxic peroxynitrite (ONOO -) and therefore decreasing NO availability for smooth muscle relaxation function [14,15]. All these processes lead to vascular system diseases such as atherosclerosis and arterial hypertension [1].…”
Section: Introductionmentioning
confidence: 99%
“…ROS plays an essential role in regulating endothelial function and vascular tone [4] in promoting systemic inflammation, endothelial dysfunction, and vascular remodeling [2,4]. Additionally, superoxide anion (O 2 -) interacts with nitric oxide (NO), producing highly toxic peroxynitrite (ONOO -) and therefore decreasing NO availability for smooth muscle relaxation function [14,15]. All these processes lead to vascular system diseases such as atherosclerosis and arterial hypertension [1].…”
Section: Introductionmentioning
confidence: 99%
“…. Naime, pad rSO 2 predstavlja upozoravajući znak za nastanak cerebralne ishemije, koja je u početku reverzibilna, ukoliko se primene mere koje utiču na dotok kiseonika do mozga i nivo moždane potrošnje kiseonika 12, [16][17][18] . Dejstvom na faktore koji utiču na dopremenje kiseonika do moždanih ćelija (povećanje cerebralnog i sistemskog srednjeg arterijskog pritiska, povećanje parcijalnog pritiska kiseonika u arterijskoj krvi, minutnog volumen srca, inspiratorne frakcije kiseonika, nivoa hemoglobina u krvi) ili smanjenjem cerebralne potrošnje kiseonika (povećanje dubine anestezije) primena šanta može i da se izbegne 12,18,19 .…”
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