Hypothesis review: The direct interaction of food nanoparticles with the lymphatic system

Lü, Wei; Guo, Jingke; Zhou, Jingran; Liu, Ke; Liu, Shutao; Gao, Guanzhen; Wang, Huiqin; Ding, Wei; Rao, Pingfan

doi:10.1016/j.fshw.2012.08.003

Cited by 12 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have hypothesized that food antioxidant nanoparticles can directly interact with MALT, including macrophages and therefore be of great physiological importance. 13 Playing key role in mediating innate or adaptive immune responses, macrophage is of particular interest for studying the interaction between micro/nano-materials and MALT. Macrophages capture and translocate organic or nonorganic particles, e.g., lipid liposome, 14 and TiO 2 microparticles or nano-particles, 15 polystyrene particles with various biomacromolecule surface coating, 16 and glyco-NPs in different shapes.…”

Section: Introductionmentioning

confidence: 99%

Direct interaction of food derived colloidal micro/nano-particles with oral macrophages

et al. 2017

Self Cite

View full text Add to dashboard Cite

Like any typical food system, bone soup (or broth), a traditional nourishing food in many cultures, contains a colloid dispersion of self-assembled micro/nano-particles. Food ingestion results in the direct contact of food colloidal MNPs with immune cells. Will they ever interact with each other? To answer the question, MNPs and NPs were separated from porcine bone soup and labeled with Nile Red, and their uptake by murine oral macrophages and its consequent effects were investigated. Colloidal particle samples of UF-MNPs and SEC-NP were prepared from porcine bone soup by ultrafiltration (UF) and size-exclusion chromatography, respectively. Their mean hydrodynamic diameters were 248 ± 10 nm and 170 ± 1 nm with dominant composition of protein and lipid. Particles in both samples were found to be internalized by oral macrophages upon co-incubation at particle/cell ratios of 14,000/1. In normal oral macrophages, the particle uptake exerted influence neither on the cellular cytosolic membrane potential (V mem ) nor mitochondrial superoxide level, as were indicated with fluorescent dyes of DiBAC 4 (3) and MitoSOX Red, respectively. However, when oral macrophages were challenged by peroxyl radical inducer AAPH, the engulfment of UF-MNPs and SEC-NPs mitigated the peroxyl radical induced membrane hyperpolarization effect by up to 70%, and the suppression on the oxygen respiration in mitochondria by up to 100%. Those results provide evidence of the direct interaction between food colloidal particles with immune cells, implying a possible new mode of food-body interaction.

show abstract

Section: Introductionmentioning

confidence: 99%

Direct interaction of food derived colloidal micro/nano-particles with oral macrophages

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…These nanoparticles, including the BLG nanoparticles in this study, are formed during the boiling preparation, and their formation results from regular food preparation rather than the subjective nanoparticle preparations [ 33 ]. The investigations on their constituent components, self-assembly behavior, cytotoxicity, and bioactivity could provide not only a new perspective for the “food–body” interaction [ 34 , 35 ] but also a prototype system for nanomaterials. The studies on the nanoparticles derived from TCM decoctions have navigated the fabrication of protein nanoparticles by using proteins from Radix Glycyrrhizae [ 3 ] and Semen Armeniacae Amarum [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide Nanoparticles from Isatis indigotica Fort. Root Decoction: Diversity, Cytotoxicity, and Antiviral Activity

Gao

Wang

et al. 2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

It has been revealed that numerous nanoparticles are formed during the boiling preparation of traditional Chinese medical decoctions and culinary soups. They may possess physiological effects different from those of constituent components and are worth paying attention to but are barely noticed and investigated as of yet. In this study, six groups of nanoparticles, whose size ranged from 57 to 300 nm, were successfully isolated from the decoction of Isatis indigotica Fort. root, according to their particle size by the means of size-exclusive chromatography. All of the obtained nanoparticles have a high content of polysaccharides, which distinguishes them from the disclosed BLG protein nanoparticles. They also have high similarities in other compositions, surface charge, and stimuli responses. However, four out of these six nanoparticles (F2, F3, F4, and F5) exhibited significant antiviral activity against influenza virus H1N1, and their antiviral activities and cytotoxicity towards MDCK cells varied with their sizes. It suggested that the antiviral efficacy of BLG decoction could also be from its nanoparticles besides its well-known antiviral phytochemicals. It also implied that the biological effects of these polysaccharide nanoparticles, including cytotoxicity and antiviral activity, may be correlative with the physicochemical properties, especially the particle size.

show abstract

“…e nanoparticles less than 200 nm can enter the macrophages, significantly reduce the oxidative stress level of cells, and show the strong oxidation resistance [27], with the effect of detoxification [28]. When substances with antioxidant activity are introduced into the human body, they will cause changes in the Evidence-Based Complementary and Alternative Medicine content of some free radicals to give full play to their antioxidant effect, thus causing changes in the meridian EPD value [10][11][12][13][14][15][16][17]. Compared with other acupoints, the EPD signal-to-noise ratio between the 12 meridians on the left side of the Source-Sea (Yuan-He) acupoint is higher and suitable for monitoring [10].…”

Section: Discussionmentioning

confidence: 99%

“…The dermal acupuncture meridian electrical potential difference (EPD) also can be real-time monitored to observe and compare various medications' and foods' meridian tropism, for volunteers' acupoint antioxidant intervention [ 10 , 11 ] and taking medicine and food functional materials, such as Cordyceps militaris [ 12 ], Inonotus obliquus (Fr.) Pilat [ 13 ], Dendrobium officinale Kimura et Migo [ 14 ], herbal drink [ 15 ], tea [ 16 , 17 ], and so on.…”

Section: Introductionmentioning

confidence: 99%

“…e dermal acupuncture meridian electrical potential difference (EPD) also can be real-time monitored to observe and compare various medications' and foods' meridian tropism, for volunteers' acupoint antioxidant intervention [10,11] and taking medicine and food functional materials, such as Cordyceps militaris [12], Inonotus obliquus (Fr.) Pilat [13], Dendrobium officinale Kimura et Migo [14], herbal drink [15], tea [16,17], and so on. erefore, in order to study the antioxidative capacity of red yeast rice and the effects on EPD of 12 acupuncture meridians (the meridian tropism of red yeast rice), the pH value, oxidation reduction potential (ORP), ABTS, FRAP, T-SOD, and particle size distribution of red yeast rice were analyzed and the left 12 acupuncture meridians EPD were real-time monitored.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

Wang

Guo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Red yeast rice is a traditional Chinese medicine and food that has been purported to color food, ferment, and lower cholesterol. In order to study the antioxidative capacity of red yeast rice and the effects on electrical potential difference (EPD) of 12 acupuncture meridians, the pH value, oxidation reduction potential (ORP), ABTS, FRAP, T-SOD, and particle size distribution of red yeast rice were analyzed. 20 volunteers were recruited and randomly divided into two groups, the red yeast rice group (10 g red yeast rice and 40 g water) and control CK group (50 g water). The left 12 acupuncture meridians’ EPD was real-time monitored. Samples were taken at the 10th minutes. The whole procedure continued for 70 minutes. It is shown that the pH value of the red yeast rice was 4.22, the ORP was 359.63 mV, the ABTS was 0.48 mmol Trolox, the FRAP was 0.08 mmol FeSO4, the T-SOD was 4.71 U, and the average particle size was 108 nm (7.1%) and 398.1 nm (92.9%). The results of 12 acupuncture meridians’ EPD showed that the red yeast rice can significantly affect the EPD of stomach, heart, small intestine, and liver meridians.

show abstract

Hypothesis review: The direct interaction of food nanoparticles with the lymphatic system

Cited by 12 publications

References 23 publications

Direct interaction of food derived colloidal micro/nano-particles with oral macrophages

Direct interaction of food derived colloidal micro/nano-particles with oral macrophages

Polysaccharide Nanoparticles from Isatis indigotica Fort. Root Decoction: Diversity, Cytotoxicity, and Antiviral Activity

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

Contact Info

Product

Resources

About