2019
DOI: 10.1101/537365
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Hypothesis-Testing Improves the Predicted Reliability of Neuroscience Research

Abstract: Critics often cite statistical problems as prime contributors to the "reproducibility crisis" of science, expressing great concern about research that bases major conclusions on single pvalued statistical tests. The critics also argue that the predicted reliability of neuroscience research in particular is low because much of the work depends heavily on small experimental sample sizes and, hence, its statistical tests lack adequate "power." It isn't known how common the practice of basing major conclusions on … Show more

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“…These studies are often statistically underpowered and therefore even positive results obtained in these conditions should not be considered sufficient evidence to draw solid conclusions. Importantly, this need is not exclusive to BMI but also pertains to closely related fields like neuroscience and cognitive psychology [49,50]. Nonetheless, specific characteristics and constraints of BMI scenarios make this approach more difficult.…”
Section: At a Methodological Levelmentioning
confidence: 99%
“…These studies are often statistically underpowered and therefore even positive results obtained in these conditions should not be considered sufficient evidence to draw solid conclusions. Importantly, this need is not exclusive to BMI but also pertains to closely related fields like neuroscience and cognitive psychology [49,50]. Nonetheless, specific characteristics and constraints of BMI scenarios make this approach more difficult.…”
Section: At a Methodological Levelmentioning
confidence: 99%
“…They showed how this approach can provide rigorous interim monitoring of the trials and efficient assessment of the durability of vaccine efficacy. They presented a simple and rigorous framework to consider the totality of evidence when evaluating the benefit of a COVID-19 vaccine in reducing SARS-CoV-2 infection, COVID-19, and severe COVID-19 [8].…”
Section: Literature Surveymentioning
confidence: 99%