2016
DOI: 10.3389/fonc.2016.00134
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Hypothesis: The Intratumoral Immune Response against a Cancer Progenitor Cell Impacts the Development of Well-Differentiated versus Dedifferentiated Disease in Liposarcoma

Abstract: Well-differentiated/dedifferentiated (WD/DD) liposarcoma is a rare malignancy of adipocyte origin (“fat cancer”). Tumors may be entirely WD, WD with a DD component, or rarely DD without a clear WD component. WD tumors are low grade and generally indolent, while tumors with a DD component are high grade and behave much more aggressively, with a modest potential for distant metastasis. The presence of cancer progenitor cells in WD/DD liposarcoma is suggested by clinical evidence and reported research findings. I… Show more

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Cited by 2 publications
(1 citation statement)
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“…Our study also suggests that further laboratory‐based investigation regarding high grade development in this disease is indeed warranted. Some of these efforts have already been initiated by our group and others 17–19 with the potential to elucidate disease‐defining biological mechanisms that may also have important applications to other more common cancers.…”
Section: Discussionmentioning
confidence: 99%
“…Our study also suggests that further laboratory‐based investigation regarding high grade development in this disease is indeed warranted. Some of these efforts have already been initiated by our group and others 17–19 with the potential to elucidate disease‐defining biological mechanisms that may also have important applications to other more common cancers.…”
Section: Discussionmentioning
confidence: 99%