Hypothyroidism and associated acute renal failure

Joshi, Bhushan; Jones, Daniel W.; Rochford, A.; Giblin, Louise

doi:10.1258/jrsm.2008.080302

Cited by 14 publications

(14 citation statements)

References 5 publications

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“…There are several case reports of both acute renal failure [ 1 , 5 ] and paralytic ileus[ 6 , 7 ] occurring in untreated hypothyroidism. However both these complications appearing in the same patient has not been reported.…”

Section: Case Presentation and Discussionmentioning

confidence: 99%

“…These were reversible with thyroxine therapy. Rhabdomyolysis, another rare but known manifestation of hypothyroidism can also result in acute kidney injury but it is usually associated with another precipitating factor such as drugs or trauma[ 5 ]. Our patient however had no evidence of rhabdomyolysis.…”

Section: Case Presentation and Discussionmentioning

confidence: 99%

“…The available evidence suggests that renal impairment may start as quickly as two weeks in to the hypothyroid state and it recovers fully with thyroxine replacement[ 9 ]. The long term impact (if any) of hypothyroidism on renal function is unknown[ 5 ].…”

Section: Case Presentation and Discussionmentioning

confidence: 99%

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Hypothyroidism causing paralytic ileus and acute kidney injury - case report

et al. 2011

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We present a patient with severe hypothyroidism complicated by paralytic ileus and acute kidney injury. A 65 year old male patient, diagnosed with hypothyroidism one year ago was transferred to our unit in a state of drowsiness and confusion. He was severely hypothyroid and had paralytic ileus and impaired renal function at the time of transfer. Hypokalaemia was present, and was likely to have contributed to the paralytic ileus and this together with dehydration was likely to have contributed to renal injury. Nonetheless, hypothyroidism is very likely to have been the principal precipitant of both these complications, and both paralytic ileus and acute kidney injury improved with thyroxine replacement. Unfortunately, the patient died unexpectedly eight days after admission to the unit.Hypothyroidism may induce de novo acute kidney injury or it may exacerbate ongoing chronic kidney disease. This rare complication is assumed to be due to the hypodynamic circulatory state created by thyroid hormone deficiency. Paralytic ileus is an even rarer fatal manifestation of hypothyroidism and is thought to be due to an autonomic neuropathy affecting the intestines that is reversible with thyroxine replacement. To our knowledge, both these complications have not been observed in a single patient so far.It is important that clinicians are aware of these rare manifestations of hypothyroidism as in most occasions, thyroxine deficiency may be missed, and treatment can reverse the complications.

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Section: Case Presentation and Discussionmentioning

confidence: 99%

Section: Case Presentation and Discussionmentioning

confidence: 99%

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Hypothyroidism causing paralytic ileus and acute kidney injury - case report

et al. 2011

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“…ARF begins to improve 2 weeks aft er initiation of levothyroxine therapy as massive PE. In literature, majority of cases except one started to improve from the two weeks (Joshi et al 2009). In our case, 2 weeks aft er pericardiocentesis, levothyroxine and oral hydration treatment renal function tests and electrolyte levels began to return to normal.…”

Section: Discussionmentioning

confidence: 46%

Newly diagnosed primary hypothyroidism applicant with massive pericardial effusion and acute renal failure

Ateş

Kaplan

Yılmaz

2016

Endocrine Regulations

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Massive PE and acute renal failure due to primary hypothyroidism is a rare clinical condition. Primary hypothyroidism should be kept in mind in patients with symptoms like shortness of breath, chest pain, and generalized edema; moreover, when acute renal failure and PE were detected. It should be considered that patient's biochemical parameters can improve starting from the two weeks after levothyroxine treatment started with pericardiocentesis in severe symptomatic patients.

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“…Association between renal failure and hypothyroidism is documented in previous case reports, but it's not found usually in textbooks. Electrolyte imbalance is seen in hypothyroidism, but associated renal impairment without underlying cause is rare (3) .…”

Section: Introductionmentioning

confidence: 99%