Hypothyroidism and non-alcoholic fatty liver disease: A coincidence or a causal relationship?

Janota, Barbara; Szczepańska, Elżbieta; Adamek, Brygida; Janczewska, Ewa

doi:10.4254/wjh.v15.i5.641

Cited by 4 publications

(5 citation statements)

References 66 publications

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“…A number of metabolic pathways in the liver, including lipogenesis, lipid oxidation and gluconeogenesis, are partially regulated by TH. In vitro studies revealed that TH significantly increases hepatic autophagy processes; thus, TH-mediated autophagy seems to be one of the most important pathways in the mobilization of hepatic TG and in releasing FFAs for mitochondrial β-oxidation [53][54][55].…”

Section: Autophagy and Thyroid Hormonesmentioning

confidence: 99%

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak-Drozd,

Niziński,

Kasprzak

et al. 2024

IJMS

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is influenced by a variety of factors, including environmental and genetic factors. The most significant outcome is the alteration of free fatty acid and triglyceride metabolism. Lipotoxicity, impaired autophagy, chronic inflammation, and oxidative stress, as well as coexisting insulin resistance, obesity, and changes in the composition of gut microbiota, are also considered crucial factors in the pathogenesis of MASLD. Resveratrol is a polyphenolic compound that belongs to the stilbene subgroup. This review summarises the available information on the therapeutic effects of resveratrol against MASLD. Resveratrol has demonstrated promising antisteatotic, antioxidant, and anti-inflammatory activities in liver cells in in vitro and animal studies. Resveratrol has been associated with inhibiting the NF-κB pathway, activating the SIRT-1 and AMPK pathways, normalizing the intestinal microbiome, and alleviating intestinal inflammation. However, clinical studies have yielded inconclusive results regarding the efficacy of resveratrol in alleviating hepatic steatosis or reducing any of the parameters found in MASLD in human patients. The lack of homogeneity between studies, low bioavailability of resveratrol, and population variability when compared to animal models could be the reasons for this.

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Section: Autophagy and Thyroid Hormonesmentioning

confidence: 99%

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak-Drozd,

Niziński,

Kasprzak

et al. 2024

IJMS

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“…The Mediterranean diet fits this dietary model and is recommended for individuals with hypothyroidism [3,18]. This diet can have a beneficial effect in preventing metabolic disorders that may develop during the underlying condition [3,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…A special focus should be placed on thyroid hormones and all the liver-endocrine relationships that regulate hepatic metabolism to maintain metabolic homeostasis [2]. They control the oxidation of fatty acids, their accumulation, and the de novo production of carbohydrates and influence hepatic insulin sensitivity [2,3]. In patients with hypothyroidism, metabolic processes in the liver are disrupted, which can lead to hepatic steatosis [4].…”

Section: Introductionmentioning

confidence: 99%

“…Dietary habits aimed at preventing the aforementioned abnormalities include adopting an anti-inflammatory diet rich in dietary fiber, plant-based products, and unsaturated fats while eliminating processed foods, fructose-rich products, and those that lead to a caloric surplus [16,17]. The Mediterranean diet fits this dietary model and is recommended for individuals with hypothyroidism [3,18]. This diet can have a beneficial effect in preventing metabolic disorders that may develop during the underlying condition [3,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Janota,

Adamek,

Szczepańska

et al. 2023

Metabolites

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Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver and body composition have not yet been comprehensively analyzed in the context of lifestyle. This study aimed to assess the selected lifestyle factors and quality of life in the context of the development of NAFL (non-alcoholic fatty liver) in women diagnosed with hypothyroidism. This study included 134 women categorized into three groups: with hypothyroidism and NAFL, with only hypothyroidism, and with only NAFL. We compared the groups concerning the KomPAN and WHOQOL-BREF questionnaires, anthropometric measurements, body composition parameters, and the stage of liver steatosis. The individuals with NAFL most frequently consumed lard, fried dishes, processed meats, red meat, sweets, and sweetened beverages. The individuals with hypothyroidism without coexisting NAFL exhibited the highest satisfaction with health. The NAFL group had the highest average body fat percentage. Selected lifestyle aspects influenced the development of NAFL in women diagnosed with hypothyroidism. Women’s overall quality of life did not vary depending on the coexisting medical conditions. Preventive programs should promote the following: the regular consumption of meals, the appropriate energy supply, physical activity, mental health support, and striving for proper body composition parameters.

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“…In hypothyroidism, thyroid gland function is affected by lifestyle, including eating behaviors and physical activity [1]. Notably, hypothyroidism predisposes patients to develop metabolic disorders, particularly lipid-related ones, which, however, develop only in specific types of patients [2,3]. Furthermore, thyroid hormones, as pleiotropic compounds, participate in the regulation of the distribution and metabolism of lipids in muscles, influencing the oxidation and transport of fatty acids in skeletal muscles [4].…”

Section: Introductionmentioning

confidence: 99%

Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders

Janota,

Szczepańska,

Noras

et al. 2023

Metabolites

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The lifestyle causes of metabolic disorders in patients with hypothyroidism should be investigated. We aimed to assess the lifestyle and quality of life of women diagnosed with hypothyroidism and search for the presence of differences between the lifestyle and quality of life of women with and without diagnosed lipid metabolism disorders. This study included 311 women. To assess the differences between the groups with and without metabolic disorders, a non-parametric Mann–Whitney U test was performed. Of the products that were potentially beneficial for health, statistically significant differences in the average frequency of consumption were observed for legume seeds (p = 0.014), and of the products potentially unbeneficial for health, the frequencies of consumption of fried dishes (p = 0.016) and fast-food products (p = 0.001) were significant. Only 11.9% rated their free-time physical activity as high. The quality of life was significantly different between the groups. The lifestyle was moderately appropriate. Compared with women with lipid metabolism disorders, women without them exhibited a higher frequency of correct dietary behaviors regarding the consumption of products with a potentially beneficial effect and sleeping duration. Women without lipid metabolism disorders had a better quality of life. Women with hypothyroidism should be educated about the beneficial aspects of the regular consumption of vegetables, fruits, legumes, and fish and sleeping for the optimal amount of time.

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Hypothyroidism and non-alcoholic fatty liver disease: A coincidence or a causal relationship?

Cited by 4 publications

References 66 publications

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders

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