Hypothyroidism Causing Precocious Puberty and Ovarian Torsion

Kini, Sandesh; Bhat, Ramesh Y; Kousika, Phalguna; Thunga, Chennakeshava; Handattu, Koushik; Karegowda, Lakshmikanth Halegubbi

doi:10.3126/jnps.v39i3.23815

Cited by 1 publication

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“…In our patient, pubertal development was age-appropriate. Children with hypothyroidism generally have delayed puberty; in rare cases of long-lasting untreated hypothyroidism, precocious puberty secondary to hyperprolactinemia or increased TSH levels [ 7 , 8 ] has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Myxedema Due to Autoimmune Hypothyroidism: A Rare Complication of a Common Disorder

et al. 2023

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In children, hypothyroidism usually presents non-specific symptoms; symptoms can emerge gradually, compromising a timely diagnosis. We report the case of a 13-year-old male, who was admitted to the hospital due to swelling of the torso and neck. Besides these symptoms, the child was healthy, except for a significant growth delay. Ultrasound evaluation and blood tests led to the diagnosis of myxedema secondary to severe hypothyroidism, which was due to autoimmune thyroiditis. Further investigations revealed pericardial effusion and pituitary hyperplasia, with hyper-prolactinemia. Treatment with levothyroxine led to edema regression and clinical, hemato-chemical and radiological improvement. After 6 months, growth velocity increased, although the recovery of growth already lost was not guaranteed. Brain MRI showed regression of pituitary hyperplasia. The diagnostic delay in this case was probably due to the patient’s apparent good health, and the underestimation of growth restriction. This report underlines the importance of growth monitoring in adolescence, a critical period for identifying endocrine conditions; if undiagnosed, these conditions can lead to serious complications, such as myxedema in hypothyroidism, with potential effects beyond growth on multiple organs.

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Section: Discussionmentioning

confidence: 99%