Hypothyroidism following struma ovarii tumor resection: a case report

Abstract

Struma ovarii is an infrequent ovarian tumor, and there are only few reports with detailed data of thyroid function. In several cases, malignant struma ovarii have been shown to produce hyperthyroidism, but there is no reported case of hypothyroidism following struma ovarii tumor resection. A 62-year-old white woman underwent right ovary resection that had a pathologic diagnosis of struma ovarii. After 6 days, she developed weakness, myalgia, somnolence, nausea, and arterial hypotension. Laboratory tests showed a high level of thyroid-stimulating hormone (TSH) and a decreased level thyroxin. Thyroxin replacement therapy was initiated, and the patient became completely asymptomatic. This is the first reported case of a previously asymptomatic woman who developed a definite clinical hypothyroidism after resection of a struma ovarii tumor.

Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature

“…Thyroid tissue is the predominant element of a struma ovarii, and varying clinical features of hyperthyroidism are present in 7% of patients, whereas 25–33% will have abnormal thyroid function tests without any symptoms (11) . Clinical hypothyroidism following resection of a benign struma ovarii has also been reported (18) . In our case, the thyroid function tests obtained on the third postoperative day revealed a mild hypothyroidism with slightly decreased free thyroxine and increased TSH levels.…”

A large struma ovarii tumor removed via laparoscopy in a 16-year-old adolescent

“…In 5% to 12% of cases, functional thyroid tissue may be present in struma ovarii; and classic symptoms of hyperthyroidism may be evident [2][3][4]8,16]. The functional thyroid tissue in the ovary may represent the patient's only functional thyroid tissue, and hypothyroidism may occur after resection [17,18]. It has been reported that struma ovarii normally do not exceed a diameter of 10 cm [19].…”

Primary hypothyroidism presenting as multiple ovarian cysts in an adult woman: A case report

“…Multicystic ovaries with hypothyroidism have been reported in prepubertal girls [1][2][3][4][5], but very few cases in adult females have been published [4,6]. The present report involves the case of an adult female with primary hypothyroidism with ovarian cysts.…”