Hypothyroidism provides resistance to kidney mitochondria against the injury induced by renal ischemia-reperfusion

Zazueta, Cecilia; Franco, Martha; Correa, Francisco; Garcı́a, Noemı́; Santamaría, José; Martínez-Abundis, Eduardo; Chávez, Edmundo

doi:10.1016/j.lfs.2006.12.023

Cited by 16 publications

(11 citation statements)

References 36 publications

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“…In contrast, matrix NAD + increased around 40% in mitochondria isolated from hypothyroid rats subjected to ischemia/reperfusion with respect to control mitochondria. As previously reported, the MPTP lies under the progression of the apoptotic mitochondrial pathway, providing mitochondrial cytochrome c release [19, 23]. Mitochondria isolated from ischemic/reperfused euthyroid kidney showed lower levels of cytochrome c, as compared with mitochondria isolated from reperfused kidney from hypothyroid rats (40% versus 10%) [19].…”

Section: Hypothyroidism and Mitochondriamentioning

confidence: 69%

“…Oxidative stress induces opening of the pore, which allows depletion of several compounds from the mitochondrial matrix including NAD + and cytochrome c [19, 23]. In this context, NAD + and cytochrome c content in kidney mitochondria also depend on thyroid status.…”

Section: Hypothyroidism and Mitochondriamentioning

confidence: 99%

“…Hypothyroidism protection, against nonspecific membrane leakage, has also been shown by using inhibitors of the electron transport and oxidative phosphorylation uncouplers [19, 20]. …”

Section: Hypothyroidism and Mitochondriamentioning

confidence: 99%

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Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism

Franco

Chávez

Pérez-Méndez

2011

Journal of Thyroid Research

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Hypothyroidism induces several metabolic changes that allow understanding some physiopathological mechanisms. Under experimental hypothyroid conditions in rats, heart and kidney are protected against oxidative damage induced by ischemia reperfusion. An increased resistance to opening of the permeability transition pore seems to be at the basis of such protection. Moreover, glomerular filtration rate of hypothyroid kidney is low as a result of adenosine receptors-induced renal vasoconstriction. The vascular tone of aorta is also regulated by adenosine in hypothyroid conditions. In other context, thyroid hormones regulate lipoprotein metabolism. High plasma level of LDL cholesterol is a common feature in hypothyroidism, due to a low expression of the hepatic LDL receptor. In contrast, HDL-cholesterol plasma levels are variable in hypothyroidism; several proteins involved in HDL metabolism and structure are expressed at lower levels in experimental hypothyroidism. Based on the positive influence of thyroid hormones on lipoprotein metabolism, thyromimetic drugs are promising for the treatment of dyslipidemias. In summary, hypothyroid status has been useful to understand molecular mechanisms involved in ischemia reperfusion, regulation of vascular function and intravascular metabolism of lipoproteins.

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Section: Hypothyroidism and Mitochondriamentioning

confidence: 69%

Section: Hypothyroidism and Mitochondriamentioning

confidence: 99%

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Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism

Franco

Chávez

Pérez-Méndez

2011

Journal of Thyroid Research

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“…To assess cytochrome c (cyt c) release, mitochondria were incubated with 50 μ M Ca 2+ with or without CsA for 10 min and pelleted by centrifugation. Released cyt c in the supernatant fractions and retained cyt c in pellets were analyzed by immunoblotting with anti-cyt c (1 : 2,500) as described by Zazueta et al [69]. Adenine nucleotide translocator (ANT, 1 : 1,000) content was determined as the loading marker.…”

Section: Methodsmentioning

confidence: 99%

Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening

García-Niño

Tapia

Zazueta

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Curcumin is a polyphenol derived from turmeric with recognized antioxidant properties. Hexavalent chromium is an environmental toxic and carcinogen compound that induces oxidative stress. The objective of this study was to evaluate the potential protective effect of curcumin on the hepatic damage generated by potassium dichromate (K2Cr2O7) in rats. Animals were pretreated daily by 9-10 days with curcumin (400 mg/kg b.w.) before the injection of a single intraperitoneal of K2Cr2O7 (15 mg/kg b.w.). Groups of animals were sacrificed 24 and 48 h later. K2Cr2O7-induced damage to the liver was evident by histological alterations and increase in the liver weight and in the activity of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase in plasma. In addition, K2Cr2O7 induced oxidative damage in liver and isolated mitochondria, which was evident by the increase in the content of malondialdehyde and protein carbonyl and decrease in the glutathione content and in the activity of several antioxidant enzymes. Moreover, K2Cr2O7 induced decrease in mitochondrial oxygen consumption, in the activity of respiratory complex I, and permeability transition pore opening. All the above-mentioned alterations were prevented by curcumin pretreatment. The beneficial effects of curcumin against K2Cr2O7-induced liver oxidative damage were associated with prevention of mitochondrial dysfunction.

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“…Moreover, the action of thyroid hormones has been associated with mitochondrial membrane permeability [17]. Evidence already relates thyroid hormones to the highly conserved adaptive and protective cellular stress response [18][19][20][21][22], and mitochondrial transmembrane potential appears to regulate activation, proliferation or programmed T cell death via oxidative stress-dependent mechanisms [18]. Thus, these data provide the lead to investigate the level of molecular interaction of thyroid hormones and CsA in vivo.…”

Section: Discussionmentioning

confidence: 99%

Blood lymphocyte blastogenesis in patients with thyroid dysfunction: ex vivo response to mitogen activation and cyclosporin A

et al. 2010

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Lymphocytes from hypothyroid patients exhibited reduced response to PHA and lower sensitivity to CsA compared with control, which could be attributed to their reduced activation capability coexisting with hypothyroidism. In hyperthyroxinaemic samples, the actions of high CsA concentrations were mostly targeted toward activated lymphoblasts. Considering the cellular targets that thyroid hormones and CsA may share, the therapeutic implications of their cross-talk need careful consideration.

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Hypothyroidism provides resistance to kidney mitochondria against the injury induced by renal ischemia-reperfusion

Cited by 16 publications

References 36 publications

Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism

Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism

Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening

Blood lymphocyte blastogenesis in patients with thyroid dysfunction: ex vivo response to mitogen activation and cyclosporin A

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