Hypouricemic effect and regulatory effects on autonomic function of Shao-Yao Gan-Cao Tang, a Chinese herbal prescription, in asymptomatic hyperuricemic vegetarians

Abstract

Shao-yao Gan-Cao Tang (SYGCT) is a popular Chinese herbal prescription which is composed of Paeoniae Radix and Glycyrrhizae Radix. The uric acid-lowering effects and regulatory effects on autonomic functions of SYGCT in vegetarians with asymptomatic hyperuricemia were evaluated in the present study. All the hyperuricemic vegetarians in experimental group and the normal healthy subjects in control group were administered SYGCT three times daily for 4 weeks. The blood levels of uric acid and general autonomic system function examinations were performed at baseline and after 4-week treatment. The activities of autonomic function were evaluated by a modified method from Wenger's analyses of autonomic variables. After 4-week treatment of SYGCT, a significant reduction of serum uric acid levels was found in the hyperuricemic vegetarians. SYGCT could increase the sympathetic activities of the hyperuricemic vegetarians with deficient-syndrome, but had no significant effects in the excess-syndrome subjects.

Efficacy and Safety of Chinese Medicinal Herbs for the Treatment of Hyperuricemia: A Systematic Review and Meta‐Analysis

“…Uricosuric drugs (i.e., probenecid and benzbromarone) that reduce the serum uric acid concentration (SUA) by increasing the renal excretion of uric acid and xanthine oxidase inhibitors (i.e., allopurinol) that decrease serum uric acid by inhibiting uric acid synthesis have been the mainstays of conventional HUE treatment [8]. Although these treatments have very good results as hypouricemic agents, they may be associated with gastrointestinal reactions, liver and kidney damage, and other adverse effects [9, 10], and, in rare cases, allopurinol has been associated with reactive hepatitis and fulminant hepatic failure [11].…”

Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCaT cells

“…(Glycyrrhizae Radix et Rhizoma) in a 2:1 ratio (Kim 2010). JYGCT is used clinically and pharmacologically in the treatment of backache, muscle pain, acute abdominal pain, neuralgia, bronchial asthma, and painful peripheral neuropathy (Hidaka et al 2009;Hinoshita et al 2003;Kim 2010;Tsuji et al 2012;Wu et al 2007). However, an inhibitory effect of JYGCT on skin inflammation has not been reported.…”

Chemical interaction between Paeonia lactiflora and Glycyrrhiza uralensis , the components of Jakyakgamcho‐tang, using a validated high‐performance liquid chromatography method: Herbal combination and chemical interaction in a decoction

“…Although GU can moderate spasms and alleviate pain, this effect is only seen when combined with PL, as in JGT 9 . JGT has been clinically and pharmacologically applied to prevent muscle cramps and inhibit the contraction of skeletal muscle 10 , reduce uric acid, regulate autonomic functions 11 , relax intestinal smooth muscle 12 , and relieve painful peripheral neuropathy 13 . These therapeutic effects of JGT are considered to be related to the combination and interaction of multiple components of the above two compositional herbs.…”