Hypovitaminosis C in hospitalized patients

Fain, Olivier; Pariès, J.; Jacquart, B; Moël, G. Le; Kettaneh, A.; Stirnemann, Jérôme; Héron, Célia; Sitbon, M; Taleb, Chérifa; Letellier, E.; Betari, B; Gattegno, Liliane; Thomas, M

doi:10.1016/j.ejim.2003.08.006

Cited by 97 publications

(87 citation statements)

References 22 publications

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“…Decreased serum vitamin C levels are quite common among hospitalized adults, particularly among alcoholics, the elderly and malnourished individuals 1,2 . A full-blown clinical picture of scurvy is rarely seen in adults, but there have been case reports and circumstances in which scurvy has been evident in patients with chronic kidney disease or cancer 3 .…”

Section: Introductionmentioning

confidence: 99%

Scurvy in a patient with AIDS: case report

Maltos

Silva

Bernardes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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We report the case of a 35-year-old homeless alcoholic and illicit drug user, with AIDS, who was admitted to the emergency unit complaining of asthenia and a weight loss of 30kg over the preceding three months. Clinical and laboratory data confirmed a diagnosis of marasmus, bacterial pneumonia, chorioretinitis caused by Toxoplasma gondii and oral Candida infection. The patient also presented loss of tongue papillae, gingival hypertrophy, perifollicular hyperkeratosis and hemorrhage, coiled, corkscrew-like hair, anemia, hypoalbuminemia, increased C-reactive protein levels and low serum vitamin C levels. The patient developed severe gastric hemorrhage, with hemodynamic instability and terminal disseminated intravascular coagulopathy.

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Section: Introductionmentioning

confidence: 99%

Scurvy in a patient with AIDS: case report

Maltos

Silva

Bernardes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…Long-term AA deficiency leads to scurvy that is caused by defective collagen synthesis (15). Primates, a few rodents such as the osteogenic disorder (ODS) rat (16), and guinea pigs (17) have lost the ability to synthesize AA because of mutations in the l-gulonolactone oxidase gene, which is essential for the AA biosynthetic pathway (18,19). Therefore, they must obtain AA from dietary sources.…”

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confidence: 99%

Effects of Ascorbic Acid Deficiency on Protein and Lipid Oxidation in Livers from SMP30/GNL Knockout Mice

Amano

Sato

Kishimoto

et al. 2013

J Nutr Sci Vitaminol

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Summary Ascorbic acid (AA) functions as an electron donor and scavenges reactive oxygen species such as superoxide, singlet oxygen, and hydroxyl radicals in vitro. However, little is known about the effect of an AA deficiency on protein and lipid oxidation levels in the liver. Therefore, we measured the levels of protein carbonyl and thiobarbituric acid reactive substances (TBARS) in livers from senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice. These mice are deficient in AA, because they lack the SMP30/GNL gene, which is essential for the biosynthesis of AA in vivo. To track the effect of an AA deficiency, at 30 d of age, mice were divided into the following four groups: AA (2) SMP30/GNL KO, AA (1) SMP30/GNL KO, AA (2) wild type (WT), and AA (1) WT. The AA (1) groups were given water containing 1.5 g/L AA, whereas the AA (2) groups received water without AA for 57 d. All mice were fed an AA-free diet. Subsequently, protein carbonyl levels in livers from AA (2) SMP30/GNL KO mice were significantly higher than those from the other three groups; however, TBARS levels were not significantly different among the four groups. Therefore, AA must act as an anti-oxidant for proteins but might not directly protect lipid oxidation in the liver.

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“…Studies have documented vitamin C deficiency among certain specialized populations, such as the elderly 2 and hospitalized inpatients. 3 In this case report, we describe scurvy as a secondary cutaneous complication of the primary fixed psychotic delusion regarding food intake. Although diagnosis in this case was straightforward, treatment of the underlying psychosis will be crucial to preventing further episodes of food restriction.…”

Section: Discussionmentioning

confidence: 95%