Hypovitaminosis D in Children with Hashimotos Thyroiditis

Sönmezgöz, Ergün; Özer, Samet; Yılmaz, Resul; Önder, Yalçın; Bütün, İlknur; Bilge, Serap

doi:10.4067/s0034-98872016000500009

Cited by 24 publications

(20 citation statements)

References 39 publications

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“…Screening for vit-D deficiency and replacement therapy if necessary has been recommended [22]. Levels of vit-D were observed to be significantly lower in children with HT [23]. A negative correlation between vit-D and TPO antibodies was found in our study.…”

Section: Discussionsupporting

confidence: 63%

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

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Background: This study was designed to investigate the vitamin D (vit-D) and vitamin B12 (vit-B12) levels and their correlation with anti-thyroid peroxidase (anti-TPO) antibodies in patients with autoimmune hypothyroidism. Methods: A total of 130 patients diagnosed with autoimmune hypothyroidism were included in the study retrospectively. The patients were divided into two groups as those having vit-B12 levels below 200 pg/mL (n = 60) and vit-B12 levels equal to or above 200 pg/mL (n = 70). These two groups were compared in terms of age, sex, thyroid-stimulating hormone (TSH), free-T4 (FT4), vit-D, and anti-TPO. The correlation between vit-B12 and anti-TPO levels was also investigated in these groups. Patients were then divided into four groups according to their vit-D levels. Patients with normal vit-D levels (25[OH]D >30 ng/mL; n = 5), those with vit-D insufficiency (20–30 mg/mL; n = 9), those with vit-D deficiency (10–20 ng/mL; n = 43), and those with severe vit-D deficiency (<10 ng/mL; n = 73). These four groups were compared in terms of age, gender, TSH, FT4, vit-B12, and anti-TPO levels. In addition, the correlation between levels of vit-D and anti-TPO was also investigated. Results: We found that vit-B12 deficiency and vit-D deficiency were associated with autoimmune hypothyroidism, and that there was a negative correlation between vit-B12 and vit-D levels and anti-TPO antibodies in these patients. Conclusion: In patients with autoimmune hypothyroidism, vit-D and vit-B12 deficiency should be investigated at the time of diagnosis and periodically on follow-ups.

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Section: Discussionsupporting

confidence: 63%

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Aktaş

2019

Med Princ Pract

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“…It should be noted, however, that the AITD group was older and had higher creatinine levels [59]. In pediatric patients with HT vs. healthy controls, a higher prevalence of VitD deficiency was also found [60][61][62][63]. However, in an analysis of pediatric patients with type 1 DM with vs. without HT, 25(OH)D levels < 20 ng/mL were found in both groups, with no difference between the two [64].…”

Section: Data In Hashimoto's Thyroiditis/chronic Autoimmune Thyroiditismentioning

confidence: 83%

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

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Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

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“…Camurdan et al, as well as Evliyaoğlu et al, observed that children with newly diagnosed HT had significantly lower 25(OH)D 3 concentrations and higher prevalence of vitamin D deficiency (defined as 25(OH)D 3 < 15.2 ng/ml and ≤ 20 ng/ml, respectively) than healthy controls (44,54). The results were confirmed Sönmezgöz et al in a group of 136 Turkish children (68 with HT and 68 controls) (55). In the study of Evliyaoğlu et al vitamin D deficient children had more than 2 times increased risk of HT (OR 2.28, 95% CI 1.21-4.3) (44).…”

Section: Hashimoto's Thyroiditismentioning

confidence: 66%

“…In the study of Evliyaoğlu et al vitamin D deficient children had more than 2 times increased risk of HT (OR 2.28, 95% CI 1.21-4.3) (44). However, none of these studies was able to show the relationship between vitamin D deficiency and the severity of thyroid dysfunction (44,54,55). Lower calcidiol levels and higher rates of vitamin D deficiency were observed also in a study on Egyptian children with HT.…”

Section: Hashimoto's Thyroiditismentioning

confidence: 95%

Vitamin D and autoimmune thyroid diseases

Kochman¹

2017

PNM

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S u m m a r yVitamin D is one of the most important factors regulating calciuam and phosphorus homeostasis and bone metabolism. In the last years increasing evidences suggest an important role of vitamin D deficiency in many extra-skeletal disorders, such as metabolic syndromes, cardiovascular diseases, cancers, infections and autoimmune disorders, including rheumatoid arthritis, Crohn disease, multiple sclerosis and type 1 diabetes mellitus. Many studies has shown also an association of vitamin D deficiency with occurrence and development of autoimmune thyroid diseases including Hashimoto's thyroiditis, postpartum thyroiditis and Graves' disease. In recent years there are increasing data indicating that vitamin D supplementation may prevent these pathologies or alleviate their course. Some studies suggest also that vitamin D may influence thyroid function. This review presents current data on the relationship of vitamin D and thyroid autoimmunization and function. The effects of vitamin D supplementation on the development and progression of autoimmune thyroid disease have also been discussed. S t r e s z c z e n i e Witamina D jest jednym z głównych czynników regulujących homeostazę wapnia i fosforu oraz metabolizm kostny. W ostatnich latach coraz więcej dowodów wskazuje na ważną rolę niedoboru witaminy D w wielu schorzeniach spoza układu kostnego, takich jak zespoły metaboliczne, choroby układu sercowo-naczyniowego, nowotwory, infekcje oraz zaburzenia autoimmunizacyjne, w tym reumatoidalne zapalenie stawów, choroba Leśniowskiego-Crohna, stwardnienie rozsiane czy cukrzyca typu 1. Wiele badań wykazało także związek między niedoborem witaminy D a chorobami autoimmunizacyjnymi tarczycy, w tym zapaleniem tarczycy Hashimoto, poporodowym zapaleniem tarczycy i chorobą Gravesa-Basedowa. W ostatnich latach coraz więcej danych wskazuje na to, że uzupełnianie niedoboru witaminy D może zapobiegać tym patologiom lub łagodzić ich przebieg. Niektóre badania sugerują także, że witamina D może mieć wpływ na czynność hormonalną gruczołu tarczowego. W artykule przedstawiono najnowsze doniesienia dotyczące związku witaminy D z procesami autoimmunizacyjnymi w tarczycy i jej czynnością hormonalną. Omówiono także wpływ suplementacji witaminą D na rozwój i przebieg autoimmunizacyjnych chorób tarczycy.

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Hypovitaminosis D in Children with Hashimotos Thyroiditis

Abstract: Vitamin D deficiency is more common in children with HT than healthy controls.

Cited by 24 publications

References 39 publications

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vitamin D and autoimmune thyroid diseases

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Hypovitaminosis D in Children with Hashimotos Thyroiditis

Abstract: Vitamin D deficiency is more common in children with HT than healthy controls.

Cited by 24 publications

References 39 publications

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vitamin D and autoimmune thyroid diseases

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Product

Resources

About

Hypovitaminosis D in Children with Hashimotos Thyroiditis