Hypovitaminosis D is Associated with Endothelial Dysfunction in Patients with Metabolic Syndrome

Oruç, Coşkun Umut; Akpınar, Yunus Emre; Amikishiyev, S.; Üzüm, Ayşe Kubat; Salmaslıoğlu, Artür; Gürdöl, Figen; Ömer, Beyhan

doi:10.2174/1570161114666161003093443

Cited by 16 publications

(13 citation statements)

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“…Endothelial dysfunction plays a key role in vascular diseases such as HTN. Vitamin D deficiency affecting the EC may precipitate HTN [22] (Figure 3). Significant impairment in the acetylcholine-induced aortic relaxation, increased sensitivity to the hypertensive effects of angiotensin II, and increased expression of angiotensin II infusion-induced hypertrophy-sensitive myocardial genes in endothelial-specific VDR knockout mice compared to control mice suggest the potential role of endothelial VDR in EC function and blood pressure control and the therapeutic role of VDR agonists in the management of EC dysfunction-related CVD [21].…”

Section: Vascular Diseasementioning

confidence: 99%

“…Low levels of vitamin D have been associated with increased risk of CVD such as coronary artery disease (CAD) [5], myocardial infarction (MI) [6–7], hypertrophy [8], cardiomyopathy [9–10], fibrosis [11–12], heart failure (HF) [13–14]. In addition, deficiency of vitamin D has been found in arterial diseases, including aneurysm [15–16], peripheral arterial disease (PAD) [17–19], arterial calcification [20], hypertension (HTN) [21–22] and atherosclerosis [23] (Figures 2 and 3). The low levels of vitamin D in these studies may be due to different confounding factors such as environment, age, sex, socioeconomic status, and nutritional status.…”

Section: Introductionmentioning

confidence: 99%

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Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

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Section: Vascular Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

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“…Nitric oxide was shown to be lower and endothelin was shown to be higher in patients with vitamin D insufficiency/deficiency compared to control group. 18 Vitamin D insufficiency could have impaired parenchymal blood supply through impairing endothelial functions and leading to more parenchymal injury.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis

et al. 2017

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Background & Objective:During the course of the autoimmune thyroid diseases, ultrasonography change parallel to histopathology. Vitamin D is associated with autoimmune diseases and thus can affect thyroid blood flow. Our aim was to investigate the relationship between vitamin D insufficiency/deficiency and thyroid hemodynamic indices in patients with Hashimoto thyroiditis.Methods:A total of 93 patients who presented to Sakarya University Endocrinology outpatient clinic from April to September 2016 and diagnosed with Hashimoto thyroiditis were included in this study. Clinical and serologic data, thyroid antibodies and 25(OH)D3 were evaluated. Mean peak systolic velocity(mPSV), mean end-diastolic velocity (EDV), mean resistive index (RI) flows of superior and inferior thyroid arteries were measured with B-mode Doppler ultrasonography.Results:Vitamin D insufficiency/deficiency was detected in 59 (63.4%). TPO Ab and TgAb levels were found higher in patients with vitamin D insufficiency/deficiency. In the normal vitamin D group, superior thyroid artery mPSV (32.21±6.73cm/s) and EDV(13.27±2.80 cm/s) were higher than in the low vitamin D group [mPSV (28.32±8.99cm/s) and EDV(10.67±3.68 cm/s)] (P=0.034, P=0.001, respectively). Inferior thyroid artery EDV value was higher in the normal compared to the low vitamin D group (0.032). RI measured in all arteries were higher in the vitamin D insufficient/deficient group compared to the Vitamin D normal group (p=0.001).Conclusion:Vitamin-D insufficiency/deficiency has led to reduced parenchymal blood supply and increased micro-vascular resistance in Hashimoto thyroiditis patients.

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“…Observational studies have shown a negative association between low serum concentrations of [25(OH)D] and components of MetS, such as fasting glycemia, arterial hypertension, and triglycerides [ 6 – 8 ]. Conversely, a few studies have demonstrated that vitamin D supplementation was beneficial in decreasing serum triglycerides, waist circumference, insulin resistance, and biomarkers of cardiometabolic risk in healthy adult individuals and patients with MetS [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

et al. 2020

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Background Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting. Systematic review registration PROSPERO registration number CRD42019123212

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Hypovitaminosis D is Associated with Endothelial Dysfunction in Patients with Metabolic Syndrome

Abstract: Vitamin D deficiency seen in MetS patients is more prominent in the presence of ED. Hypovitaminosis D may affect endothelial cells, and participate in the development of hypertension.

Cited by 16 publications

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Role of Vitamin D in Cardiovascular Diseases

Role of Vitamin D in Cardiovascular Diseases

Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis

Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

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