Hypoxaemia and cirrhosis of the liver.

Funahashi, A; Kutty, Ahamed V.P.; Prater, Sandra L.

doi:10.1136/thx.31.3.303

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…In other studies, MEF25-75 was decreased (6,23,24). Closing capacity and closing volume were described to be elevated (24)(25)(26)(27), and re-sidual volume was increased , especially in the lower zones of the lung (26).…”

Section: Discussionmentioning

confidence: 77%

Hypoxemia in Infants with Biliary Atresia

Seidenberg,

Kluge,

Rodeck

et al. 1992

J. pediatr. gastroenterol. nutr.

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SummaryHypoxemia in liver cirrhosis has been attributed to increased pulmonary perfusion; lung function abnormalities have rarely been found in adults. In infants, however, smaller airways and the disproportion in size between the enlarged liver and abdominal cavity leading to lung compression by elevated diaphragms may well suggest that ventilation disturbances play an important role in the development of hypoxemia. We examined lung functions, ventilation‐perfusion scans, chest radiographs, and blood gases in air and 80% oxygen in 19 infants with biliary atresia (mean age 14 months) and found maximum flows at functional residual capacity (VmaxFRC) markedly decreased [48%± 29% (mean± SD)] and thoracic gas volume (TGV) elevated (156%± 30.2%). Po2 was <9.3 kPa in seven of 19 patients, in whom TGV was higher compared with the other patients (182% vs. 141%, p < 0.005). However, the decrease in Po2, was much more closely correlated to the amount of shunting (r = 0.62, p < 0.05) than to the reduced airway patency (VmaxFRC/TGV, r = 0.41, p = 0.08). We conclude that airway narrowing probably by lung compression is present more frequently in infants than in adults with liver disease. We found some evidence that hyperinflation contributes to the observed low Po2 values, possibly aggravated by inadequate vasoconstriction to hypoxic stimuli. However, pulmonary shunting independent of ventilatory disturbances more readily explained hypoxemia already present in these infants.

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Section: Discussionmentioning

confidence: 77%

Hypoxemia in Infants with Biliary Atresia

Seidenberg,

Kluge,

Rodeck

et al. 1992

J. pediatr. gastroenterol. nutr.

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“…67 Other investigators who have studied patients with cirrhosis and clinical ascites could find no consistent relationship between premature closure of the airways and the degree of hypoxemia. 68 Identification of ventilation-perfusion abnormalities is important because therapy with supplemental oxygen can usually reverse the arterial hypoxemia in patients with such abnormalities. 15 A final consideration about impaired gas exchange in patients with chronic liver disease, although not vascular in origin, concerns the occurrence of pleural effusions.…”

Section: Hepatic Cirrhosismentioning

confidence: 99%

Pulmonary Aspects of Chronic Liver Disease and Liver Transplantation

Krowka¹,

Cortese²

1985

Mayo Clinic Proceedings

147

105

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A vast spectrum of pulmonary pathologic conditions occurs in association with chronic liver diseases, and clinically important manifestations, such as arterial hypoxemia, can result. Both pulmonary vascular and parenchymal abnormalities can contribute to the dysfunction, as evidenced by results of pulmonary function tests and gas exchange studies. The clinical implications of identifying such pulmonary problems range from alleviation of symptoms, especially dyspnea, to comprehensive assessment of patients before and after liver transplantation. Physicians should be aware of these potential pulmonary disorders that can complicate liver disease and liver transplantation so that management of affected patients can be improved.

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“…Respiratorische Alkalose, Störungen des Gasaustausches, Hypoxämie [11], in trapulmonale Shunts [17], VentilationsPerfusions-Missverhältnis [12], Erniedri gung der Diffusionskapazität [27], Erhö hung des «closing volume» [12] und Ver änderungen der «closing capacity» [11,12] sowie Pleuraergüsse sind in der Litera tur als Manifestationen der gestörten At mung bei chronischen Lebererkrankun gen beschrieben worden [15,16,24,34] …”

Section: Introductionunclassified

Störungen der Atmung bei Patienten vor und nach Lebertransplantation

Hagenah

Gw²

1987

Respiration

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In 61 patients with chronic hepatic insufficiency parameters of regulation of ventilation, mechanics of breathing and gas exchange were determined pre and in 16 patients post liver transplantation. Preoperatively disturbances of control with increased central respiratory drive resulting in chronic hyperventilation and maladaptation of perfusion to ventilation were found. Successful liver transplantation resulted in regression of these disturbances to different degrees. We therefore conclude that disturbances of respiration in patients with chronic hepatic insufficiency are reversible after successful liver transplantation

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Hypoxaemia and cirrhosis of the liver.

Cited by 10 publications

References 29 publications

Hypoxemia in Infants with Biliary Atresia

Hypoxemia in Infants with Biliary Atresia

Pulmonary Aspects of Chronic Liver Disease and Liver Transplantation

Störungen der Atmung bei Patienten vor und nach Lebertransplantation

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