Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult

Abstract

Hypoxaemic reperfusion during resuscitation from a severe global ischaemic cerebral insult is associated with statistically significantly fewer histopathological changes of the brain than in controls. This is associated with a superior neurological outcome.

Significance of arterial hyperoxia and relationship with case fatality in traumatic brain injury: a multicentre cohort study

“…To this end, our analysis, which included pre-defined end points describing the onset of lung injury during ICU or hospital stay, makes confounding from pulmonary variables less likely. Third, our study used a priori definitions of hyperoxia as suggested by prior animal24 and observational studies 18. Though our study suggests an effect of hyperoxia on in-hospital case fatality, we were unable to define the precise PaO 2 level at which the maximal risk for death would occur and we were also unable to explore the time of exposure to hyperoxia as ABGs in PI were not time-stamped.…”

“…Hyperoxia was defined as PaO 2 of 300 mm Hg (39.99 kPa) or greater,18 24 hypoxia as PaO 2 of less than 60 mm Hg (7.99 kPa) or PaO 2 /FiO 2 ratio less than or equal to 30025 26 and normoxia not classified as hyperoxia or hypoxia 18 24. The primary outcome measure was in-hospital case fatality.…”

Arterial Blood Gas Tensions After Resuscitation From Out-of-Hospital Cardiac Arrest

“…The median amount of ABG measurements per patient during the first 24 hours was eight (IQR, [6][7][8][9][10][11]. Arterial oxygen values were higher in those with a good outcome, whereas no Figure 2, A and B.…”

“…Recently, two studies have suggested harm from exposure to hyperoxia in CA patients treated with or without TH (6,7). The proposed mechanisms include the formation of harmful oxygen radicals and vasoconstriction of cerebral blood vessels, resulting in brain ischemia (8)(9)(10). Hypocapnia reduces intracerebral pressure (ICP) and may increase cerebral perfusion pressure, but may also cause vasoconstriction and ischemia, which is shown to be deleterious in patients with traumatic brain injury (TBI) (9).…”

Myocardial ischemia in intestinal postischemic shock: The effect of hypoxemic reperfusion

“…This was further supported by the finding of a lower degree of lipid peroxidation as assessed by the measurement of plasma malondialdehyde (MDA) and hydroxyalkenals (7). In a subsequent study on the same animal model, the beneficial effect of hypoxemic reperfusion was confirmed by the milder degree of tissue injury as it was assessed by histologic studies of brain (8).…”