ulmonary embolism (PE) is a major health problem associated with a significant morbidity and mortality particularly in older patients. The overall annual incidence is approximately more than 1 case per 1,000 person-years, 1 but this increases markedly with advancing age. [1][2][3][4] The incidence is distributed extremely unevenly over the ages: 1 case per 1,000,000 person-years for children aged less than 15 years, 72.4 cases per 100,000 person-years for adults aged 40-54 years and 2.8 cases per 1,000 personyears for those aged 85-89 years. 2,3,5 Autopsy series have shown that PE is responsible for, or at least accompanies, approximately 12% of inhospital deaths and this rate increases to 20% for the patients aged 70 years and over. 6,7 Kniffin et al reported a 1-year mortality for PE of 39% in patients older than 65 years, 3 and Sakuma et al reported that the relative risk of mortality from PE was 417.76 for the patients aged over 79 years. 8 The high incidence of PE requires physicians to maintain a high level of suspicion in order to make a prompt diagnosis and initiate appropriate treatment, which is even more important for elderly patients who have higher mortality rates. On the other hand, physicians have to deal with the challenge of diagnosing suspected PE in elderly because older patients with PE may present with atypical clinical features in the absence of the usual indices. However, the clinical presentation of PE in the elderly population has not been extensively investigated. In the present study, the
Circulation Journal Vol.69, August 2005hospital records of patients with documented PE were analyzed according to age, and risk factors, presenting symptoms and signs, arterial blood gas (ABG) analysis, electrocardiographic (ECG) and echocardiographic (ECHO) findings and, pulmonary vascular obstruction scores (PVOs) as a marker of severity of the disease, were compared for a better definition of the disease characteristics in the older population.
Methods
Study Population and DesignThe study was carried out at Gazi University, a large teaching hospital in Ankara. Hospital records between 1998 to 2003 from the Chest Department's database were used to identify patients who had received a final diagnosis of PE, which was established according to the protocol previously published by Prospective Investigation of Pulmonary Embolism Diagnosis investigators. 9 Patients diagnosed with pneumonia were not included in the study.Patients who met the entry criteria were stratified into 2 groups as older (≥65 years old) or younger (<65 years old) patients. The risk factors for PE were defined as follows: 10,11 immobilization (at least 2 days' bed rest in the 2 weeks prior to admission), pregnancy (includes postpartum period within the 3 months prior to admission), estrogen or oral contraceptive use, stroke, obesity (body mass index >27 kg/m 2 ), trauma (within past 3 months), recent operation (within past 6 weeks), malignancy, recent history of long travel (>6 h within 1 week), chronic obstructive lung disease (COPD...