Hypoxia

Meier, Gilbert W.

doi:10.1016/b978-0-12-269950-4.50008-4

Cited by 9 publications

(3 citation statements)

References 95 publications

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“…Hypoxia, generally defined as a reduction in oxygen availability below the organism's requirements, is invariably present in complications of birth and is believed to be the cause of the subsequent intellectual impairment which is frequently observed (Gottfried, 1973;Meier, 1971). The importance of fetal hypoxia in complications of pregnancy is more difficult to assess for other, often potentially more damaging, factors are also present.…”

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confidence: 99%

The behavioral effects of prenatal hypoxia in the rat

McCullough

Blackman

1976

Developmental Psychobiology

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Pregnant rats were exposed to an oxygen depleted atmosphere (13% oxygen in nitrogen) at normal pressure in 2-hr daily sessions extending over approximately the last 14 days of pregnancy. Their progeny were compared with control progeny in terms of age of eye-opening, open-field behavior, and Hebb-Williams maze problem solving ability. The groups were not distinguishable by their performance in the open-field, but the experimental animals opened their eyes significantly earlier and made significantly more errors on Hebb-Williams maze problems.

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confidence: 99%

The behavioral effects of prenatal hypoxia in the rat

McCullough

Blackman

1976

Developmental Psychobiology

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“…The consequences of prenatal and early postnatal oxygen deprivation have been the object of concern for a number of years. Although the majority of such studies have dealt with mammalian forms (see reviews in Meier, 1958Meier, , 1971, compelling evidence indicates that oxygen deprivation in avian embryos during specific prenatal periods can produce specific deficits. Meier & Menzel(l955), for example, found that oxygen deprivation of the medial lethal extent at Day 8 of incubation, produced by submerging the eggs in warm distilled water for several minutes, led t o particular postnatal visual-motor disturbances, this period of deprivation being a time during which considerable development of the visual-motor system was occurring.…”

Section: Discussionmentioning

confidence: 99%

Learning deficits in the neonatal peking duckling produced by decreased oxygen consumption during late prenatal periods: A cautionary note

Heaton

Klein

1980

Developmental Psychobiology

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Neonatal Peking ducklings were tested in a detour problem-solving task following replacement of the shell overlying the air space of the egg on Prenatal Day 24 (total incubation period: 27 days) with a plastic wrap. This procedure, a common practice in behavioral embryology, resulted in a significant decrease in oxygen consumption, and a protracted retardation in the mastery of the learning task, with experimental ducklings solving the problem at a mean age of 5.27 days, compared with 2.32 days for controls. These results serve to underscore the problems that may be encountered as a result of any interference with the integrity of the egg during the prenatal period.

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“…Take a specific problem: the inference of early hypoxic trauma in the appreciation of cerebral palsy, mental retardation, and related neurological-psychological problems in the school-age child (Meier, 1971). A relation between hypoxia at birth and behavioral dysfunction has been seriously advanced for well over a century.…”

Section: Meiermentioning

confidence: 99%