Hypoxia: A Potent Regulator of Angiogenesis Through Extracellular Matrix Remodelling

Karavasili, Katerina; Koolwijk, Pieter

doi:10.1007/978-3-031-19616-4_8

Cited by 2 publications

(1 citation statement)

References 160 publications

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“…Both effects were suppressed by echinomycin that inhibits the activity of HIF-1, revealing its reliance on HIF mediated transcriptional regulation ( Yonekura et al, 2013 ). Because hypoxia governs the composition, deposition, posttranslational modifications, and rearrangement of the ECM, hypoxia-induced vascular remodeling is intricately controlled by adjusting the activities of ECM-modifying enzymes, which subsequently regulate the availability of matricellular proteins and growth factors ( Karavasili and Koolwijk, 2022 ).…”

Section: Biophysical Interpretation Of Tumor Microenvironment (Tme)mentioning

confidence: 99%

Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis

Lee,

Cho,

Kim

et al. 2024

Front. Cell Dev. Biol.

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Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation of cancer mechano-responses. The biophysical interactions between cancer cells and their dynamic microenvironment are attributed to force-dependent alterations in molecular pathways that trigger the structural reorganization of intracellular organelles and their associated genetic modifications. Recent studies underscore the role of oxygen concentration in cancer metastasis. Suppressed oxygen levels promote the development of invasive phenotypes and aggressive proliferation of cancer cells, accompanied by remodeling of tumor microenvironment encompassing the modulation of physical settings of extracellular matrix. This review summarizes the role of biophysical interactions between cancer cells and their surroundings in determining cancer progression. Biophysical interpretation of the tumor microenvironment and cancer progression could provide further insights into the development of novel biomedical technologies for therapeutic cancer treatment.

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Section: Biophysical Interpretation Of Tumor Microenvironment (Tme)mentioning

confidence: 99%

Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis

Lee,

Cho,

Kim

et al. 2024

Front. Cell Dev. Biol.

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Assessing Wound Healing in Vivo Using a Dual-Function Phosphorescent Probe Sensitive to Tissue Oxygenation and Regenerating Collagen

Wang,

Zhang,

et al. 2024

ACS Appl. Mater. Interfaces

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Levels of tissue oxygenation and collagen regeneration are critical indicators in the early evaluation of wound healing. Traditionally, these factors have been assessed using separate instruments and different methodologies. Here, we adopt the spatially averaged phosphorescence lifetime approach using Re I -diimine complexes (Re I -probe) to enable simultaneous quantification of these two critical factors in healing wounds. The topically applied, biocompatible Re I -probe penetrates wound tissue effectively and selectively binds to collagen fibers. During collagen regeneration, the phosphorescence lifetimes of the collagen-bound probe significantly extend from an initial range of 4.5−6.5 μs on day 0 to 5.5−8.5 μs by day 7. Concurrently, unbound probes in the tissue interstitial spaces exhibit a phosphorescence lifetime of 4.5−5.2 μs, revealing the oxygenation states. Using phosphorescence lifetime imaging microscopy (PLIM) and a frequency domain phosphorescence lifetime measurement (FD-PLM) system, we validated the dual-functionality of this Re I -probe in differentiating healing stages in chronic wounds. With its noninvasive, quantitative measurement capabilities for cutaneous wounds, this Re I -probe-based approach offers promising potential for early wound healing diagnosis.

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Hypoxia: A Potent Regulator of Angiogenesis Through Extracellular Matrix Remodelling

Cited by 2 publications

References 160 publications

Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis

Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis

Assessing Wound Healing in Vivo Using a Dual-Function Phosphorescent Probe Sensitive to Tissue Oxygenation and Regenerating Collagen

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