Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis

Hu, Fanlei; Mu, Rong; Zhu, Jiaxin; Shi, Lianjie; Li, Yingni; Liu, Xu; Shao, Wenwei; Li, Guiye; Li, Minghui; Su, Yin; Cohen, Philip L.; Qiu, Xiaoyan; Li, Zhanguo

doi:10.1136/annrheumdis-2012-202444

Cited by 104 publications

(81 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, positive the scores for synovitis (a), the score for pannus formation (b), the score for bone destruction (c), and the levels of VEGF (d) and HIF-1α (e) in the synovium feedback regulation of the HIF-1α and VEGF pathways can trigger angiogenesis during hypoxia [45]. In vitro studies have confirmed that the absence of HIF-1α attenuates angiogenesis through a VEGF-dependent mechanism [46].…”

Section: Discussionmentioning

confidence: 95%

Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels

Chen

Zhu

et al. 2017

Clin Rheumatol

View full text Add to dashboard Cite

The objective of the present study is to evaluate the inhibitory effects of taxol (PTX) on angiogenesis in a collagen-induced arthritis (CIA) mouse model. Collagen II (C II) and complete Freund's adjuvant (CFA) were used in C57BL/6 (H-2b) mice to generate the CIA model. Random grouping was performed in the normal control group, CIA model group, PTX 1.5 mg/kg group, PTX 1.0 mg/kg group, and PTX 0.5 mg/kg group. Arthritis index scores, tissue pathology scores, and synovium microvessel density (MVD) analysis were performed. Immunohistochemistry and enzyme-linked immunosorbent assay were used to detect the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-α (HIF-1α). The correlation between MVD and pathological scores and between MVD and the expression of VEGF as well as HIF-1α in the synovium were also evaluated. After PTX treatment, the three intervention group arthritis index scores were reduced when compared with the CIA group. The total histological scores in the three PTX treatment groups were lower than those in the CIA group. Similarly, PTX significantly alleviated the scores for synovitis, pannus formation, and bone destruction. Compared with the CIA group, the MVD of the three intervention groups decreased in a dose-dependent manner. The expression of VEGF and HIF-1α in synovial tissues and serum also significantly decreased after PTX treatment. Further analysis showed that MVD and pathological scores and MVD and expression of VEGF as well as HIF-1α in the synovium were positively correlated. PTX may alleviate CIA by suppressing angiogenesis, providing new insights into the treatment of rheumatoid arthritis (RA). VEGF and HIF-1α may be targets for PTX suppression of microvessel formation.

show abstract

Section: Discussionmentioning

confidence: 95%

Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels

Chen

Zhu

et al. 2017

Clin Rheumatol

View full text Add to dashboard Cite

show abstract

“…Furthermore, the association of smoking with disease occurrence in individuals who carry the shared epitope and worse disease outcome is well established [18]. It is confirmed that local factors such as hypoxia, which is thought to be important in Immune signal transduction, are also relevant [19]. However, the detailed molecular mechanisms of the disease are still elusive.…”

Section: Discussionmentioning

confidence: 95%

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2

Miao

Qin

et al. 2015

International Immunopharmacology

View full text Add to dashboard Cite

“…Under hypoxic conditions, disruption of HIF-1α in Müller cells attenuates the increases of retinal vascular leakage and inflammation 13. Fanlei Hu et al demonstrated that hypoxia and HIF-1α potentiate TLR signalling-induced inflammation in rheumatoid arthritis 14. TLR signalling-induced innate immunity is linked to the hypoxic response through NF-κB in macrophages 15.…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 3 activation drives the inflammatory response in oxygen-induced retinopathy in rats

Min

Zhang

et al. 2014

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis

Abstract: Our findings suggest that hypoxia and HIF-1α may function in conjunction with TLR-stimulated innate immune responses to drive inflammation in RA. This pathway may serve as a therapeutic target for the disease.

Cited by 104 publications

References 22 publications

Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels

Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2

Toll-like receptor 3 activation drives the inflammatory response in oxygen-induced retinopathy in rats

Contact Info

Product

Resources

About