Hypoxia and its Modification in Bladder Cancer: Current and Future Perspectives

Lodhi, Taha; Song, Yee Pei; West, Catharine M L; Hoskin, Peter; Choudhury, Ananya

doi:10.1016/j.clon.2021.03.001

Cited by 17 publications

(11 citation statements)

References 120 publications

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“…Hypoxia, an essential characteristic of the TME, results in enhanced resistance to damage by tumor cells due to an adaptive modulatory response ( 81 ). In the setting of glioma, hypoxia further promotes malignant pathogenesis as well as drug resistance ( 82 ).…”

Section: Major Immune Cell Recruitment Factors Within the Glioma Micr...mentioning

confidence: 99%

Recruitment mechanisms and therapeutic implications of tumor-associated macrophages in the glioma microenvironment

et al. 2023

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As one of the main components of the glioma immune microenvironment, glioma-associated macrophages (GAMs) have increasingly drawn research interest. Primarily comprised of resident microglias and peripherally derived mononuclear macrophages, GAMs are influential in a variety of activities such as tumor cell resistance to chemotherapy and radiotherapy as well as facilitation of glioma pathogenesis. In addition to in-depth research of GAM polarization, study of mechanisms relevant in tumor microenvironment recruitment has gradually increased. Suppression of GAMs at their source is likely to produce superior therapeutic outcomes. Here, we summarize the origin and recruitment mechanism of GAMs, as well as the therapeutic implications of GAM inhibition, to facilitate future glioma-related research and formulation of more effective treatment strategies.

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Section: Major Immune Cell Recruitment Factors Within the Glioma Micr...mentioning

confidence: 99%

Recruitment mechanisms and therapeutic implications of tumor-associated macrophages in the glioma microenvironment

et al. 2023

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“…This study developed a novel signature according to HRL as a predictor of UVM prognosis and that LINC02367 may be an effective target for clinical intervention. Hypoxic environment has been revealed markedly impacted on manifold malignant tumors, like hepatocellular carcinoma, carcinoma of bladder, carcinoma of lungs and glioma [39][40][41][42]. In bladder cancer, an 8-gene hypoxia signature accurately predict patient prognosis and showed a signi cant correlation with immune in ltration [43].…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-Related lncRNA Correlates with Prognosis and Immune Microenvironment in Uveal Melanoma

Chen,

Cheng

et al. 2024

Preprint

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Background Genes related to hypoxia are correlated to the prognosis of a variety of solid malignant tumors. However, How hypoxia related lncRNA function in Uveal Melanoma is still rare. Methods From TCGA database, eighty UVM samples were incorporated. Prognostic HRL was screened by COX univariate analysis and Pearson correlation analysis. HRL characteristics were constructed using Lasso analysis. Gene enrichment analysis revealed the linkage of HRLs to immune features. CCK8 assay was adopted to measure the propagation of MuM2B cells, while tumor invasion and migration were appraised by Transwell and Wound-healing experiments. Inflammatory factors and macrophage polarization were evaluated by qPCR. Results 621 prognostic HRLs were screened and was constructed in 12 HRLs. Risk score showed salient correlation with survival time of UVM patients. In addition, HRL was correlated with diverse key immune checkpoints, revealing possible targets for immunotherapy. Immune-related pathways were highly enriched in high-risk group. Protective HRL, LINC02367, was saliently associated with microenvironment and survival time of UVM patients. In vitro assays demonstrated LINC02367 significantly affected the propogation and migration of MuM2B. LINC02367 modulates macrophage polarization through inflammatory factor levels thereby affecting the immune microenvironment Conclusions In our study, a novel HRL signature was developed to predict the prognosis of UVM patients. HRLs are potential biomarkers and therapeutic targets for UVM.

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“…On the other hand, it has been demonstrated that hyperbaric oxygen promotes immune responses in solid tumors and disrupts hypoxiamediated immunosuppression (27). Bladder cancer hypoxia is associated with genetic instability, EMT, inhibited apoptosis, and cancer progression (8). Hypoxia has been shown to affect immunotherapy by altering molecular markers, immune cell trafficking, and angiogenesis to cause immunosuppression through a HIF-1-dependent signature (28).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, chemoresistance of bladder cancer cells is also associated with hypoxia by activation of HIF-1α-associated autophagy (7). Hypoxia can also influence the genetic instability and malignant progression of MIBC, which are related to metastasis (8).…”

Section: Introductionmentioning

confidence: 99%

Identifying a hypoxia related score to predict the prognosis of bladder cancer: a study with The Cancer Genome Atlas (TCGA) database

Zhang¹,

Li²,

Li³

et al. 2021

Transl Androl Urol

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Background: Recurrence is common in bladder cancer, with a hypoxic tumor microenvironment (TME) playing a role in genetic instability and prognosis of bladder cancer. However, we still lack practical hypoxia related model for predicting the prognosis of bladder cancer. In this study, we identified new prognosisrelated hypoxia genes and established a new hypoxia score related signature. Methods:The Gene Set Variation Analysis (GSVA) algorithm was utilized to calculate the hypoxia score of bladder cancer cases found on the The Cancer Genome Atlas (TCGA) database on the gene expression profiles. The cases were first divided into low-and high-hypoxia score groups and then differentially expressed genes (DEGs) expression analysis was conducted. Hypoxia-related genes were identified using weighted gene co-expression network analysis (WGCNA). We then conducted a protein-protein interaction (PPI) network and carried out functional enrichment analysis of the genes that overlapped between DEGs and hypoxia-related genes. LASSO Cox regression analysis was used to establish a hypoxia-related prognostic signature, which was validated using the GSE69795 dataset downloaded from GEO database.Results: Results from Kaplan-Meier analysis showed that patients with a high hypoxia score had significantly poor overall survival compared to patients with low hypoxia score. We selected 270 DEGs between low-and high-hypoxia score groups, while WGCNA analysis identified 1,313 genes as hypoxiarelated genes. A total of 170 genes overlapped between DEGs and hypoxia-related genes. LASSO algorithms identified 29 genes associated with bladder cancer prognosis, which were used to construct a novel 29-gene signature model. The prognostic risk model performed well, since the receiver operating characteristic (ROC) curve showed an accuracy of 0.802 (95% CI: 0.759-0.844), and Cox proportional hazards regression analysis proved the model an independent predictor with hazard ratio (HR) =1.789 (95% CI: 1.585-2.019) (P<0.001).The low-risk score patients had remarkably longer overall survival than patients with a higher score (survival rate 71.06% vs. 23.66%) in the The Cancer Genome Atlas (TCGA) cohort (P<0.0001) and in the dataset GSE69795 (P=0.0079). Conclusions:We established a novel 29-gene hypoxia-related signature model to predict the prognosis of bladder cancer cases. This model and identified hypoxia-related genes may further been used as biomarkers, assisting the evaluation of prognosis of bladder cancer cases and decision making in clinical practice.

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Hypoxia and its Modification in Bladder Cancer: Current and Future Perspectives

Cited by 17 publications

References 120 publications

Recruitment mechanisms and therapeutic implications of tumor-associated macrophages in the glioma microenvironment

Recruitment mechanisms and therapeutic implications of tumor-associated macrophages in the glioma microenvironment

Hypoxia-Related lncRNA Correlates with Prognosis and Immune Microenvironment in Uveal Melanoma

Identifying a hypoxia related score to predict the prognosis of bladder cancer: a study with The Cancer Genome Atlas (TCGA) database

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