2015
DOI: 10.1016/j.clgc.2015.03.006
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Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings

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Cited by 85 publications
(80 citation statements)
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“…4 Once stabilized and activated, HIF1 dimerizes in the nucleus where it binds to Hypoxia Responsive Elements (HREs). In this way, it regulates genes generally associated with a poor prognosis, 5,6 and with decisive roles in some stages of tumor development, including cancer cell spreading and invasion and metastasis formation. 6 One of the proteins upregulated in low oxygen conditions by HIF-1 overexpression is annexin A1 (ANXA1).…”
Section: Introductionmentioning
confidence: 99%
“…4 Once stabilized and activated, HIF1 dimerizes in the nucleus where it binds to Hypoxia Responsive Elements (HREs). In this way, it regulates genes generally associated with a poor prognosis, 5,6 and with decisive roles in some stages of tumor development, including cancer cell spreading and invasion and metastasis formation. 6 One of the proteins upregulated in low oxygen conditions by HIF-1 overexpression is annexin A1 (ANXA1).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, it is well established that PCa is exposed to fluctuating oxygen tensions due to a changing environment, and both chronic and acute hypoxia exist in PCa, as HIF-1α and VEGFA protein levels are both increased in PCa compared to benign prostate hyperplasia (BPH). 5,15,33 However, no reports have investigated the effect of LFUM on the hypoxia environment of PCa, whose primary effect on the body is limiting the blood supply.…”
Section: Discussionmentioning
confidence: 99%
“…The hypoxic microenvironment of the tumor has been confirmed to be correlated with tumor metastasis and resistance to chemotherapy and radiotherapy. 4,5 This is particularly true for PCa: Several clinical studies have proved that hypoxia is an independent prognostic indicator of poor outcome, which is detrimental to the efficacy of treatment. [6][7][8] Hypoxia within the tumors can be divided into two categories: chronic (diffusion-limited) hypoxia, in which cells far from the blood vessels are exposed to slowly decreasing concentrations of oxygen and increasing intracellular hypoxia; and acute (perfusion-limited) hypoxia, in which a sudden, intermittent, or complete reduction of blood flow lead to acute lack of oxygen and nutrients, leading to intracellular hypoxia.…”
Section: Introductionmentioning
confidence: 99%
“…TXNIP was proposed as a tumor suppressor gene in various tumors (40), including HCC (41), but its function in metastasis remains controversial. TXNIP expression levels in tumor cells of hypoxic perinecrotic areas of glioblastoma and conventional RCC are increased compared with non-hypoxic tumor cells or peritumoral tissues (42), while hypoxia often promotes cancer metastasis and leads to a poor prognosis (43,44). In an in vitro intravasation model study, overexpression of TXNIP in melanoma cells increased trans-endothelial intravasation compared with the control (26), while overexpression of TXNIP was reported to inhibit metastasis through the gene KiSS-1 metastasis-suppressor in melanoma cells (27).…”
Section: Discussionmentioning
confidence: 99%