Hypoxia at altitude and villous vascularisation in the mature human placenta

Reshetnikova, O.S.; Burton, G.J.; Milovanov, Andrej P.

doi:10.1016/s0143-4004(05)80589-2

Cited by 9 publications

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“…At high altitude, there is an increase both in the volume of fetal capillaries and in the incidence of chorangioma (Reshetnikova et al 1994a(Reshetnikova et al , 1994b. According to our research, the mean birthweight of Nepalese neonates was 26814~18.7 g, and the mean placental weight was 380.2118.7 g, significantly less than those in the Japanese group (mean birthweight 3173k449 g, mean placental weight 444446 g) (Soma 1988(Soma , 1991.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal hypoxia at high altitude can lead to villous hypervascularization in the placenta in these high mountain areas (Reshetnikova et al 1993. Chorangiosis and chorangioma in the placenta might be correlated with dissimilarity of the fetal vessel on the chorionic plate, thereby resulting in disturbance of the blood flow in the intervillous circulation.…”

Section: Discussionmentioning

confidence: 99%

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Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan

Soma¹,

Watanabe²,

Hata³

1995

Reprod. Fertil. Dev.

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It has been reported that both chorangiosis and chorangioma are increased in placentas at high altitudes. In this study, 1.14% of 2448 Japanese placentas obtained at 30-300 m had chorangiosis or chorangioma, compared with 3.24% of the Nepalese placentas (1300-3000 m) and 9.09% of the Tibetan samples (3800-4200 m). The incidence of both pathologies was significantly higher in the Himalayan groups than those of the Japanese group (P < 0.05). Obstetric complications of the 28 Japanese placentas with chorangiosis and chorangioma included Caesarean section 16 (57.1%), abruptio placentae 2 (7.14%), intrauterine growth retardation 3 (10.7%), intrauterine fetal death 4 (14.2%) and placenta praevia 4 (14.2%). Four infants (14.2%) had Apgar scores ranging from 0 to 3. Among 48 Himalayan placentas with chorangiosis and chorangioma, incidence of marked subchorionic fibrin was significantly higher (25%) than in the Japanese group (3.57%) (P < 0.05). The incidence of abnormal insertion of the cord was significantly higher (14.2%) in the Japanese group than in the Himalayan group (5%) (P < 0.05). There was no significant difference in the frequencies of intervillous thrombosis and infarction between the two groups. These findings suggest that the incidence of pathological change such as chorangiosis and chorangioma may be increased in placentas at Himalayan altitudes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%