Hypoxia enables B19 erythrovirus to yield abundant infectious progeny in a pluripotent erythroid cell line

Caillet-Fauquet, Perrine; Draps, M-L.; Giambattista, M. Di; Launoit, Yvan de; Laub, R

doi:10.1016/j.jviromet.2004.06.010

Cited by 15 publications

(8 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To determine whether the results obtained in a heterologous rabbit‐human system for MMV, that is, a widely used B19V model virus, would be predictive of the behavior of the target virus itself, the removal of B19V by 0.1‐µm−35N filtration was also investigated. Although recently the use of B19V infectivity assays has been published, 12‐14 the ubiquitous presence of fairly high titers of B19V neutralizing antibodies in pools of human plasma and consequently immunoglobulin products 15 would render the results of such assays more difficult to interpret, and thus for the current investigation a quantitative PCR method as described earlier was used 9 …”

Section: Resultsmentioning

confidence: 99%

Removal of small nonenveloped viruses by antibody‐enhanced nanofiltration during the manufacture of plasma derivatives

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Removal of small nonenveloped viruses by antibody‐enhanced nanofiltration during the manufacture of plasma derivatives

et al. 2006

View full text Add to dashboard Cite

show abstract

“…These disease states could potentially affect brain pathology. A study found that B19 grew better under hypoxic conditions [29,30]. During a B19-induced anemia, the decreased oxygen circulation and delivery to the brain could lead to neurological manifestations.…”

Section: Infection Of Other Organs and Its Resulting Effect On Brainmentioning

confidence: 99%

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

Hobbs¹,

Waseem²

2016

J Neuroinfect Dis

View full text Add to dashboard Cite

Our work has focused over the years on Primate Erythroparvovirus 1 [more commonly known as parvovirus B19 (B19)]. B19 is a human pathogen that is the causative agent of erythema infectiosum, the common rash disease of childhood. In addition to several other human diseases, B19 has also been associated with multiple brain diseases. Those brain diseases include, but are not limited to, encephalitis, encephalopathy, meningitis, meningoencephalitis, ataxia, seizures, and stroke. To date, the association has grown, but causation has not been determined. Several possible mechanisms of pathogenesis including direct infection, indirect/epigenetic, reactivation, and autoimmune/ inflammatory cytotoxicity, as well as effects due to infection of other organs have been suggested. We will also offer other hypotheses.

show abstract

“…In fact, a significant enhancement of B19V DNA replication as well as progeny virus production has been observed during B19V infection of hEPCs when they were cultured under 1% O 2 (hypoxia) [54,84–85]. Interestingly, hypoxia actually reduces the differentiation potential and the proliferation rate of the hEPCs [54].…”

Section: Hypoxic Conditions Promote Productive B19v Infection Of Erytmentioning

confidence: 99%

Human Parvovirus B19: a Mechanistic Overview of Infection and DNA Replication

Luo

Qiu

2015

Future Virol.

View full text Add to dashboard Cite

Human parvovirus B19 (B19V) is a human pathogen that belongs to genus Erythroparvovirus of the Parvoviridae family, which is composed of a group of small DNA viruses with a linear single-stranded DNA genome. B19V mainly infects human erythroid progenitor cells and causes mild to severe hematological disorders in patients. However, recent clinical studies indicate that B19V also infects nonerythroid lineage cells, such as myocardial endothelial cells, and may be associated with other disease outcomes. Several cell culture systems, including permissive and semipermissive erythroid lineage cells, nonpermissive human embryonic kidney 293 cells and recently reported myocardial endothelial cells, have been used to study the mechanisms underlying B19V infection and B19V DNA replication. This review aims to summarize recent advances in B19V studies with a focus on the mechanisms of B19V tropism specific to different cell types and the cellular pathways involved in B19V DNA replication including cellular signaling transduction and cell cycle arrest.

show abstract

Hypoxia enables B19 erythrovirus to yield abundant infectious progeny in a pluripotent erythroid cell line

Cited by 15 publications

References 45 publications

Removal of small nonenveloped viruses by antibody‐enhanced nanofiltration during the manufacture of plasma derivatives

Removal of small nonenveloped viruses by antibody‐enhanced nanofiltration during the manufacture of plasma derivatives

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

Human Parvovirus B19: a Mechanistic Overview of Infection and DNA Replication

Contact Info

Product

Resources

About