Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells

Li, Qian; Lin, Guihu; Zhang, Kaihua; Liu, Xinbo; Li, Zhantao; Bing, Xiaohan; Nie, Zhenkai; Jin, Shan; Guo, Jin; Min, Xianjun

doi:10.1016/j.bcp.2024.116415

Biochemical Pharmacology

2024

DOI: 10.1016/j.bcp.2024.116415

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Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells

Qian Li,

Guihu Lin,

Kaihua Zhang

et al.

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A rising star involved in tumour immunity: Lactylation

Zhang,

Liang,

et al. 2024

J Cellular Molecular Medi

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In recent years, continuous exploration worldwide has revealed that some metabolites produced during cellular and tissue metabolism can act as signalling molecules to exert different effects on the human body. These metabolites may act as cofactors for proteases or as post‐translational modifications linked to proteins. Lactate, a traditional metabolite, is found at high levels in the tumour microenvironment (TME). Many studies have shown that lactate influences tumorigenesis and development via different mechanisms, not only through the metabolic reprogramming of tumours but also through its significant impact on tumour immunity. Previously, tumour cells were reported to use glucose and glutamine to fuel lactate metabolism; however, lactate serves not only as an energy source for tumour cells but also as a precursor substance needed for the post‐translational modification of proteins. Recent studies identified a novel form of epigenetic modification, lactate‐mediated histone lysine lactylation (Kla) and demonstrated that histone lactylation directly stimulates chromatin after gene transcription; consequently, lactylation has become a popular research topic in recent years. This article focuses on the research progress and application prospects of lactylation in the context of tumour immunity.

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A rising star involved in tumour immunity: Lactylation

Zhang,

Liang,

et al. 2024

J Cellular Molecular Medi

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Hypoxia exposure induces lactylation of Axin1 protein to promote glycolysis of esophageal carcinoma cells

Cited by 1 publication

References 34 publications

A rising star involved in tumour immunity: Lactylation

A rising star involved in tumour immunity: Lactylation

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