2022
DOI: 10.3390/ijms23158165
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Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

Abstract: As the global aging process continues to lengthen, aging-related diseases (e.g., chronic obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly population. Aging is a complex biological process involving multiple tissues and organs and is involved in the development and progression of multiple aging-related diseases. At the same time, some of these aging-related diseases are often accompanied by hypoxia, chronic inflammation, oxidative stress, and the increased secretion of the sen… Show more

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Cited by 31 publications
(24 citation statements)
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“…In the long‐term hypoxia, the two major members of hypoxia‐inducible factors (HIFs) family including HIF‐1α and HIF‐2α are transcription factors that were shown to serve as the master indicator of hypoxia and play crucial role in the cellular response to low‐oxygen levels 66 . Both HIF‐1α and HIF‐2α are involved in managing prolonged oxidative damage in aging‐ and obesity‐related diseases 67–70 . Particularly, HIF‐1α plays a key role in the stimulation of osteoclast formation in aging‐ and obesity‐induced osteoporosis 70–72 .…”
Section: Discussionmentioning
confidence: 99%
“…In the long‐term hypoxia, the two major members of hypoxia‐inducible factors (HIFs) family including HIF‐1α and HIF‐2α are transcription factors that were shown to serve as the master indicator of hypoxia and play crucial role in the cellular response to low‐oxygen levels 66 . Both HIF‐1α and HIF‐2α are involved in managing prolonged oxidative damage in aging‐ and obesity‐related diseases 67–70 . Particularly, HIF‐1α plays a key role in the stimulation of osteoclast formation in aging‐ and obesity‐induced osteoporosis 70–72 .…”
Section: Discussionmentioning
confidence: 99%
“…FGF23, KRT18, AKT1, B2M, NOS1, AOC1, SOD2 and SOD3) did not return to the pre-ight baseline expression levels, even after 120 days. The data suggest that space conditions activate the HIF1 pathway which stimulates the expression of various hypoxiaresponsive genes such as HIF1A, HIF1AN, ARNT, ARNT2, NOS1, NOS2, NOTCH1 and RBX1, that are known to regulate a wide variety of cellular physiology including metabolic reprogramming, anti-apoptosis, migration, proliferation, amyloid β production and prion stabilization 30,31 . An interesting observation emerging from the data is the elevation of HIF1A and HIF3A post-ight.…”
Section: Multiple Frailty Related Biomarkers Are Differentially Expre...mentioning
confidence: 99%
“…When a chronic infection is established, a large amount of reactive oxygen species (ROS), chemokines and cytokines, such as IL-1b, are produced, which in turn increases inflammation and parallelly activates NF-kB-mediated HIF-1a synthesis (39,40). HIF-1a is a key transcription factor for modulating the inflammation response, because it promotes the expression of proinflammatory cytokines and chemokines (39,40). Consistent with this role is that HIF-1a-deficient mice were found to be resistant to develop inflammatory diseases; however, when they were subjected to chronic infection developed inflammatory responses and died early, compared with control animals (41)(42)(43).…”
Section: Hif-1amentioning
confidence: 99%
“…It regulates immune cell proliferation and the response to pathogens through epigenetic regulation, which is largely controlled by transcription factor hypoxia-inducible factor 1 (HIF-1α) ( 38 ). When a chronic infection is established, a large amount of reactive oxygen species (ROS), chemokines and cytokines, such as IL-1β, are produced, which in turn increases inflammation and parallelly activates NF-κB-mediated HIF-1α synthesis ( 39 , 40 ). HIF-1α is a key transcription factor for modulating the inflammation response, because it promotes the expression of proinflammatory cytokines and chemokines ( 39 , 40 ).…”
Section: Mechanisms Controlling Inflammaging and Immunosenescencementioning
confidence: 99%
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