Hypoxia in aquatic invertebrates: Occurrence and phenotypic and molecular responses

Changes in Induced-Antipredation Defense Traits and Transcriptome Regulations of Daphnia magna in Response to 5-HT1A Receptor Antagonist

“…By analyzing transcription factors and signaling pathways, we found that exposure to kairomone alone significantly activated the HIF-1α signaling pathway, suggesting that in the presence of fish kairomone, rapid activation of HIF-1a signaling elements could lead to an increase in transient movement (avoidance response) through enhanced glucose metabolism and vascular dilation . Conversely, treatment with WAY-100635 resulted in the inhibition of serotonin, orexin, oxytocin, opioid, and ecdysteroid receptor signaling pathways as well as the HIF-1α pathway.…”

“…By analyzing transcription factors and signaling pathways, we found that exposure to kairomone alone significantly activated the HIF-1α signaling pathway, suggesting that in the presence of fish kairomone, rapid activation of HIF-1a signaling elements could lead to an increase in transient movement (avoidance response) through enhanced glucose metabolism and vascular dilation. 77 Conversely, treatment with WAY-100635 resulted in the inhibition of serotonin, orexin, oxytocin, opioid, and ecdysteroid receptor signaling pathways as well as the HIF-1α pathway. In view of the important role of these pathways in metabolism, 78,79 oxidative stress, 80 growth, and reproduction, 81 the downregulation of these pathways under the influence of WAY-100635 may lead to a decrease in overall metabolic regulation of Daphnia and inhibition of body size, reproduction, and transcription.…”

Marine Bioprospecting: Enzymes and Stress Proteins from the Sea Anemones Anthopleura dowii and Lebrunia neglecta

“…Organisms that live in hydrothermal vents increase the production of superoxide dismutase and catalase [22]. The reduction in oxygen in water bodies globally due to climate change is a factor that generates hypoxic conditions, which reduces locomotion and metabolic rate and increases oxidative stress, affecting other physiological processes of organisms that must be adjusted to quickly adapt to those conditions [23]. Organisms such as crustaceans, which face changes in salinity, generate a stress response and, at the same time, metabolic disorders, affecting the production of chitin and the enzymes required to produce this [24,25].…”