Hypoxia increases the cutaneous threshold for the sensation of cold

Golja, Petra; Kacin, Alan; Tipton, Michael J.; Eiken, Ola; Mekjavic, Igor B.

doi:10.1007/s00421-004-1058-9

Cited by 30 publications

(28 citation statements)

References 40 publications

(40 reference statements)

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“…Thus, interference with the thermoregulatory integrative centres of the brain will decrease the precision of thermoregulation at both upper and lower ranges. Interestingly, hypoxia has also been shown to significantly decrease the cutaneous sensitivity of humans to cold but not to warm temperatures (Golja et al, 2004). This is consistent with the observation that rhesus monkeys exposed briefly to anoxia drastically diminished the firing rate of cutaneous cold-sensitive units (Iggo and Paintal, 1977).…”

Section: Implications For the Neurophysiological Control Of T Bsupporting

confidence: 80%

Decreased precision contributes to the hypoxic thermoregulatory response in lizards

Cadena

Tattersall

2009

Journal of Experimental Biology

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SUMMARYThe decrease in body temperature (T b ) observed in most vertebrate classes in response to hypoxia has been attributed to a regulated decrease in set-point, protecting organs against tissue death due to oxygen depletion. Hypoxia, however, imparts particular challenges to metabolic function which may, in turn, affect thermoregulation. In ectotherms, where thermoregulation is mainly behavioural, stressors that influence the propensity to move and respond to temperature gradients are expected to have an impact on thermoregulatory control. Using low oxygen as a potent stressor, we evaluated the variability and level of thermoregulation of inland bearded dragons. To examine the source of thermoregulatory variability, we studied their behaviour in an electronically controlled temperature-choice shuttle box, a constant temperature dual-choice shuttle box, and a linear thermal gradient. A significant increase in the size of the T b range was observed at the lowest oxygen concentration (4% O 2 ), reflecting a decrease in thermoregulatory precision in the temperature-choice shuttle box. This was also accompanied by a drop of ~2-4°C in T b , the drop being greatest in situations where T b must be actively defended. Situations that force the lizards to continually choose temperatures, rather than passively remain at a given temperature, lead to an increase in the variability in the manifested T b , which is further exaggerated in hypoxia. This study reveals that a decrease in thermoregulatory precision caused by a diminished propensity to move or effect appropriate thermoregulatory responses may be a contributing component in the lowering of selected body temperatures observed in many hypoxic ectotherms.

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Section: Implications For the Neurophysiological Control Of T Bsupporting

confidence: 80%

Decreased precision contributes to the hypoxic thermoregulatory response in lizards

Cadena

Tattersall

2009

Journal of Experimental Biology

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“…The primary differences between the present study and the study of Golja et al (2004) are in the size and location of the thermally stimulated area, the initial vasoconstrictor tone of the subjects, and in the response requested from the subjects. In our previous study, the subjects were requested to report whether or not they perceived cold stimuli applied to a 7.3 cm 2 area of the skin.…”

Section: Discussionmentioning

confidence: 79%

“…This is especially surprising in view of our recently reported observation of a hypoxia-induced elevation in the cutaneous threshold for cold sensation (Golja et al 2004).…”

Section: Discussionmentioning

confidence: 87%

“…Replicating the protocol of Cabanac (1972), Golja and Mekjavic (2003) investigated the effects of hypoxia on preferred hand temperature during core cooling and found no significant effects. However, in a subsequent study they observed a significant hypoxia-induced increase in the cutaneous threshold for cold sensation (Golja et al 2004). As the perception of thermal stimuli forms the basis for the sensation of thermal comfort, it was hypothesised that hypoxia would also alter the zone of thermal comfort.…”

Section: Discussionmentioning

confidence: 99%

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Moderate hypoxia does not affect the zone of thermal comfort in humans

et al. 2005

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The zone of thermal comfort was determined during normoxia and hypoxia in 15 healthy normothermic young subjects. Subjects dressed only in shorts/shorts and bikini top donned a water-perfused suit and assumed a supine position on a bench. The ambient temperature was maintained at a mean (SD) of 25.7 (0.3) degrees C. The thermal comfort zone was determined by increasing the temperature of the water perfusing the suit from cool to warm. During the heating process, subjects were instructed to report when their perception of the thermal stimulus provided by the suit changed from unpleasant to pleasant, and again from pleasant to unpleasant. The boundaries of the thermal comfort zone were assumed to be the temperatures of the water perfusing the suit at the time the subjects reported a change in the affective component of their thermal perception. In normoxia, subjects inspired room air and in hypoxia a gas mixture containing 10% O(2) in N(2). Tympanic temperature was similar in the normoxia and hypoxia conditions (P>0.05). The average (SD) lower and upper limits of the thermal comfort zone were 30.5 (1.5) and 34.7 (3.3) degrees C, respectively, during normoxia, and 30.5 (1.7) and 35.1 (3.4) degrees C, respectively, during hypoxia. No significant differences were observed between the normoxia and hypoxia conditions (P>0.05). Also, no gender-related differences were observed in the characteristics of the thermal comfort zone. The results of the present study indicate that acute hypoxic exposure simulated in the present study does not affect the zone of thermal comfort in humans.

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“…In agreement with the fi rst possibility, hypoxia has been found to alter the threshold of various thermoregulatory responses. In particular heat-induced polypnea occurs at a lower T c in hypoxic compared to normoxic adult cats [31] , warming hypoxic newborn cats to their normoxic T c increases their minute ventilation [32] , the threshold for cold sensation is increased in hypoxic men [33] , and hypoxia reduces huddling behavior in newborn rats [2] as well as the preferred T a of adult rodents [34] . Consistent with the second hypothesis is the fi nding of greater decrease in sympathetic nerve activity and more marked vasodilation in kidney, stomach and intestine with heating of young adult compared to senescent rats [27,35] .…”

Section: Effect Of Warming In Hypoxia On Regional Blood Flowmentioning

confidence: 99%

Effect of Body Warming on Regional Blood Flow Distribution in Conscious Hypoxic One-Month-Old Rabbits

Seifert

Anna²,

Rohlicek

2006

Neonatology

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Background: Previous experiments have shown that warming hypoxic infants reduces total peripheral vascular resistance. This suggests that the usual vasoconstriction of less essential vascular beds during hypoxia may be reduced and that the normal redistribution of blood flow to more vital organs may be compromised. Objective:Evaluate the effect of body warming during hypoxia on the distribution of blood flow. Methods: The fluorescent microsphere technique was used to compare regional blood flow in 1-month-old rabbits during systemic hypoxia (10% inspired O₂) with (n = 9) and without (n = 10) body warming. Blood flow was measured in brain, stomach, small intestine, hindlimb muscle, skin, and kidneys. Arterial blood pressure, whole-body O₂ consumption, arterial blood O₂ saturation and blood gases were also measured. Measurements and Main Results: In hypoxia all animals decreased body temperature (–2°C). With hypoxia blood flow increased to brain and hindlimb muscle; decreased to stomach, small intestine, and kidneys, and was unchanged in skin. The increase in brain-blood flow maintained O₂ delivery at normoxic levels. Rewarming to the normoxic body temperature significantly changed blood flow in hypoxia. Brain blood flow increased by 102 ± 30% (mean ± SEM) thereby increasing O₂ delivery by 50 ± 23% above normoxic values. Blood flow also increased to skin, stomach, and small intestine. However, O₂ delivery to these tissues remained below normoxic levels. Conclusions: Warming during hypoxia may impose an additional cardiovascular demand. The changes in the pattern of blood flow distribution with mild warming during hypoxia support the hypothesis that warming represents a significant heat stress.

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Hypoxia increases the cutaneous threshold for the sensation of cold

Cited by 30 publications

References 40 publications

Decreased precision contributes to the hypoxic thermoregulatory response in lizards

Decreased precision contributes to the hypoxic thermoregulatory response in lizards

Moderate hypoxia does not affect the zone of thermal comfort in humans

Effect of Body Warming on Regional Blood Flow Distribution in Conscious Hypoxic One-Month-Old Rabbits

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