2001
DOI: 10.1006/bbrc.2001.5927
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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

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Cited by 150 publications
(117 citation statements)
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“…Synovial Cells Produce Active HIF-1 Upon Hypoxia and TNF␣ Treatment-Hypoxia is known to induce/activate various transcription factors such as ETS-1 (20), NF-B (21), and HIF-1 (22). Among these, HIF-1 is of particular interest because it is a critical factor involved in both hypoxic and inflammatory responses (41).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Synovial Cells Produce Active HIF-1 Upon Hypoxia and TNF␣ Treatment-Hypoxia is known to induce/activate various transcription factors such as ETS-1 (20), NF-B (21), and HIF-1 (22). Among these, HIF-1 is of particular interest because it is a critical factor involved in both hypoxic and inflammatory responses (41).…”
Section: Resultsmentioning
confidence: 99%
“…Also, due to inflammation in the growing synovial membrane during RA development, there is increasing metabolic needs in the arthritic joints, resulting in insufficient oxygen uptake (17,19). It is well known that hypoxia induces the expression of a number of transcription factors involved in arthritis, such as ETS-1 (20), nuclear factor-B (NF-B) (21), and hypoxia-inducible factor-1 (HIF-1) (22). Among these, HIF-1 was shown to regulate the expression of a variety of genes implicated in arthritis, an important one being vascular endothelial growth factor, a growth factor involved in the perpetuation of the abundant vasculature found in the synovia (23).…”
mentioning
confidence: 99%
“…Importantly, there is a cross-talk between these regulatory pathways. However, the situation might be more complex, as SP1 was found to be a transcriptional target of Ets-1 (Sato and Furukawa, 2007), and Ets-1 expression is enhanced by HIF-1 (Oikawa et al, 2001). In the case of endosialin expression, we observed that the gene is regulated by hypoxia under conditions that stabilise and activate HIF-2 and/or HIF-1.…”
Section: Discussionmentioning
confidence: 99%
“…Lately, chimeric proteins of EWS and ETS transcription factors have been shown to up-regulate ID2 expression in Ewing sarcoma by binding to characterized sites within the ID2 promoter (37,38). Since ETS-1 has been demonstrated to be a direct HIF-1 target gene and is up-regulated by hypoxia (39), binding of ETS proteins to the ID2 promoter could be a possible explanation for the hypoxia-induced reporter gene activation observed after mutating the functional HBSs. It is also possible, however unlikely, that previously unidentified non-consensus HIF binding sites, potentially located in the investigated promoter regions, were responsible for the remaining hypoxia-induced reporter activity.…”
Section: Discussionmentioning
confidence: 99%