Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients

Zhang, Weijie; Chen, Cheng; Zhou, Zhihua; Gao, Shanting; Tee, Teong Jin; Yang, Liuqing; Xu, Yuanyuan; Pang, Taohong; Xu, Xiaoyu; Sun, Qi; Feng, Min; Wang, Hao; Lu, Chung‐Kuang; Wang, Guozhong; Wu, Sheng; Guan, Wenxian; Xu, Guifang

doi:10.7150/jca.19057

Cited by 31 publications

(24 citation statements)

References 31 publications

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“…Significant differences were observed within groups for the various SDT parameters. Tumor tissues subjected to SDT showed high expression levels of CD4, CD8, and CD68 and low expression levels of CD163, CD25, and FoxP3, which suggested that SDT could activate T cells, promote a shift from M2 to M1 macrophages and induce immune responses …”

Section: Resultsmentioning

confidence: 99%

“…can be used for the detection of different classes of tumor-associated macrophages (TAM), namely, M1 and M2 (immune-suppressive). 25,26 In the present study, we chose CD163 and CD68 to identify M2 macrophages and thus observed the effect of SDT on the differentiation of TAM. In addition, regulatory T cells mediating immunoregulation is one of the most important mechanisms for maintaining self-tolerance.…”

Section: Immunohistochemical Analysis Of Tumor Tissuesmentioning

confidence: 99%

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Sonodynamic therapy‐assisted immunotherapy: A novel modality for cancer treatment

et al. 2018

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Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccine. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In the present study, we found that HiPorfin (HPD)‐induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses. Meanwhile, we observed that SDT induced functional antitumor vaccination and abscopal effects in H22 tumor‐bearing mice. Furthermore, this strategy conferred an immunological memory, which could protect against tumor recurrence after the elimination of the initial tumor. These results showed important effects of SDT on immune responses.

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Section: Resultsmentioning

confidence: 99%

Section: Immunohistochemical Analysis Of Tumor Tissuesmentioning

confidence: 99%

Sonodynamic therapy‐assisted immunotherapy: A novel modality for cancer treatment

et al. 2018

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“…A 2017 study by Fu et al has shown a significant correlation between the expression of the CD68 marker characteristic to TAMs and losing expression of the epithelial marker E-cadherin, as well the presence of the mesenchymal marker vimentin [146]. proposed increased TAMs infiltration and hypoxia-inducible factor-1 alpha (HIF-1α) as potential factors stimulating the induction of EMT [154]. Likewise, TAMs induce the expression of forkhead box Q1 (FOXQ1) promoting EMT with invasion and migration properties [155].…”

Section: Tumor-associated Macrophages In Gastric Cancermentioning

confidence: 99%

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

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Brzozowska

Forma

et al. 2020

IJMS

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Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastric cancer in a subset of affected individuals. This explains why H. pylori is the only bacterium classified as a class I carcinogen by the World Health Organization. Several studies have pinpointed mechanisms by which H. pylori alters signaling pathways in the host cell to cause diseases. In this article, the authors have reviewed 234 studies conducted over a span of 18 years (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020). The studies investigated the various mechanisms associated with gastric cancer induction. For the past 1.5 years, researchers have discovered new mechanisms contributing to gastric cancer linked to H. pylori etiology. Alongside alteration of the host signaling pathways using oncogenic CagA pathways, H. pylori induce DNA damage in the host and alter the methylation of DNA as a means of perturbing downstream signaling. Also, with H. pylori, several pathways in the host cell are activated, resulting in epithelial-to-mesenchymal transition (EMT), together with the induction of cell proliferation and survival. Studies have shown that H. pylori enhances gastric carcinogenesis via a multifactorial approach. What is intriguing is that most of the targeted mechanisms and pathways appear common with various forms of cancer.EMT refers to the process by which the mesenchymal phenotype is acquired by epithelial cells (ECs) mainly via the reduction of their intracellular adhesions and proliferative capacity (Figure 1.) [47].

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“…Hypoxia influences various proteins involved in angiogenesis, such as VEGF and inducible nitric oxide (iNOS), which are closely related to TAMs' function and ultimately contribute to the formation of tumor microenvironment. Mutually, regulating the M2 phenotype functions of macrophages helps to attenuate and alleviate the hypoxic state of the tumor …”

Section: Plasticity and Function Of Macrophagesmentioning

confidence: 99%

Progress in Tumor‐Associated Macrophages: From Bench to Bedside

et al. 2018

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Tumor‐associated macrophages (TAMs) are of great interest in cancer immunology as they play an important role in the tumor microenvironment as cancer stromal cells recruited from circulating monocytes. TAMs are closely associated with tumor progression, including initiation, trophic growth, metabolism, angiogenesis, and metastasis; moreover, in clinical practice, their quantity can be related to poor prognosis. Fundamental and translational studies imply that TAMs are one of the most promising targets in tumor therapy. Herein, the biological origination and classification of TAMs, which correspond to their functions and differentiations, are reviewed in detail. In addition, recent basic research and clinical preprocess of TAMs in tumor immunotherapy are also discussed. Finally, the advances in the use of nanotechnology and TAMs for tumor therapy are discussed. This review focuses on the background and status of basic research and clinical significance of TAMs, points out the potential of TAMs in tumor immunological therapy, and clarifies the possibility of translation TAM‐targeting therapies in medicine.

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Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients

Cited by 31 publications

References 31 publications

Sonodynamic therapy‐assisted immunotherapy: A novel modality for cancer treatment

Sonodynamic therapy‐assisted immunotherapy: A novel modality for cancer treatment

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

Progress in Tumor‐Associated Macrophages: From Bench to Bedside

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