Hypoxia-inducible factor 1 and its role in viral carcinogenesis

Cuninghame, Sean; Jackson, Robert; Zehbe, Ingeborg

doi:10.1016/j.virol.2014.02.027

Cited by 64 publications

(84 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent studies, the role of HIF-1α in tumorigenesis has gradually been determined (13)(14)(15). The expression levels of HIF-1α were demonstrated to be significantly increased in multiple types of human cancer (12,13,16).…”

Section: Instructionmentioning

confidence: 99%

MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α

Yao

Cao

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. MicroRNAs (miRs) may induce mRNA degradation or inhibit protein translation by directly binding to the 3'-untranslational region of target mRNAs. It has been reported that miR-138 is downregulated in malignant melanoma (MM) cells. However, the role of miR-138 in MM cell proliferation, invasion and energy metabolism remains unknown. These were investigated using reverse transcription-quantitative polymerase chain reaction was used to evaluate the expression of miR-138 and the mRNA expression of hypoxia-inducible factor-1α (HIF-1α), as HIF-1α serves a crucial role in glycolysis, which is important for tumor growth. In addition, western blot analysis was used to detected the protein expression of HIF-1α, while MTT and Transwell assays evaluated cell proliferation and invasion, respectively. Furthermore, glucose consumption and lactic acid production were assessed. These tests were conducted using the normal human melanocyte cell line HM and the MM cell line WM451, which was transfected variously with scramble miR mimics, miR-138 mimics, miR-138 inhibitor, non-specific small interfering (si)RNA, HIF-1α siRNA, or co-transfected with miR-138 mimics and pc-DNA3.1(+)-HIF-1α plasmid. The results showed that miR-138 was significantly downregulated in MM WM451 cells compared to a normal melanocyte cell line HM. Overexpression of miR-138 significantly inhibited the proliferation and invasion of WM451 cells. These effects were similar to those induced by the siRNA-mediated knockdown of HIF-1α, a direct target of miR-138. Further investigation found that miR-138 negatively regulated the protein expression of HIF-1α in WM451 cells. Moreover, upregulation of miR-138 notably inhibited the glycolysis level, as demonstrated by reduced glucose consumption and lactic acid production,

show abstract

Section: Instructionmentioning

confidence: 99%

MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α

Yao

Cao

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that a subunit of HIF-1α gene is overexpressed in breast cancer [15]. The C1772T polymorphisms are the most widely studied, which induce proline-to-serine amino acid substitutions and associated with increased HIF-1α expression in breast cancer [16]. The C>T change at 1772 causes the increase of Pro/Ser variation at codon 582 [17].…”

Section: Discussionmentioning

confidence: 99%

The Association between the C1772T Genetic Polymorphism in Human HIF-1α Gene and Breast Cancer Risk: A Meta-analysis

Cheng¹,

Yuan²,

Liu³

et al. 2017

Chemotherapy

View full text Add to dashboard Cite

Purpose: This meta-analysis aims to investigate the association between the C1772T genetic polymorphism in human HIF-1α gene and breast cancer risk. Methods:PubMed and Embase databases were searched till October 2013 to identify eligible studies. A total of 2143 cases and 2046 controls from 6 studies were included in this paper. Allelic and genotypic comparisons between cases and controls were evaluated. Subgroup analyses by ethnicity were also performed. Results Conclusions:This meta-analysis suggests that the C1772T polymorphism is significantly associated with breast cancer risk in Asia. However, we find that the C1772T polymorphism is not associated with breast cancer risk on the whole.

show abstract

“…The beta subunit is an oxygen-independent constitutive protein located in the cell nucleus [22]. The process of alpha subunit degradation is initiated by posttranslational hydroxylation of amino acids proline 402 and proline 564 [23][24][25]. Because of hydroxylation, the alpha subunit of HIF protein is recognized by the von Hippel-Lindau protein (pVHL), a fragment of the ubiquitin ligase complex.…”

Section: Hif-1 Proteinmentioning

confidence: 99%

Hypoxia in prostate cancer

Danielska

Łuniewska-Bury²,

Kuncman³

et al. 2017

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

Most human solid tumours contain areas which are less oxygenated than normal tissues. Hypoxia increases resistance to radiotherapy, surgery and chemotherapy, and directly alters the function of tumour cells, stimulating them to de-differentiate and to release angiogenic factors with a view to increasing the blood and oxygen supply. Tumour hypoxia promotes malignant progression and metastasis formation. HIF-1 is a heterodimeric transcription factor composed of regulated HIF-1a and constitutively expressed HIF-1b. Tumour-associated activation of HIF-1a seems to be primarily, however the result of adaptation to oxygen shortage. The presence of the HIF-1a subunit overexpression has been confirmed in many tumours, in prostate cancer, among others; the role it plays in its progression is yet to be explained. Numerous studies strongly emphasize the importance of evaluating the status of the HIF-1a transcription factor in predicting the clinical and biochemical recurrence of prostate cancer and its resistance to castration. NOWOTWORY J Oncol 2017; 67, 2: 132-136

show abstract

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

Cited by 64 publications

References 169 publications

MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α

MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α

The Association between the C1772T Genetic Polymorphism in Human HIF-1α Gene and Breast Cancer Risk: A Meta-analysis

Hypoxia in prostate cancer

Contact Info

Product

Resources

About