Hypoxia inducible factor-1 signaling pathway in macrophage involved angiogenesis in materials-instructed osteo-induction

Bai, Hetian; Guo, Xiaodong; Tan, Yujie; Wang, Yue; Feng, Jing; Lei, Kexin; Liu, X.; Xiao, Yu; Bao, Chongyun

doi:10.1039/d2tb00811d

Cited by 5 publications

(4 citation statements)

References 68 publications

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“…HIF-1α, which is one of the critical regulators of chondrocyte template formation, is stably expressed in a hypoxic environment, which sustains the survival of cells by altering cellular metabolism. HIF-1α was shown to largely contribute to the construction of vascular networks during bone repair, but the direct relationship between HIF-1α and osteoblast and osteogenic activity remains controversial [114,200]. Prolonged severe hypoxia was demonstrated to have severe adverse effects on bone formation and even a series of brutal outcomes, such as necrosis, which is in line with conventional understandings of cellular activity.…”

Section: Discussionmentioning

confidence: 79%

The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering

You

Zhai

et al. 2023

IJMS

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The process of repairing significant bone defects requires the recruitment of a considerable number of cells for osteogenesis-related activities, which implies the consumption of a substantial amount of oxygen and nutrients. Therefore, the limited supply of nutrients and oxygen at the defect site is a vital constraint that affects the regenerative effect, which is closely related to the degree of a well-established vascular network. Hypoxia-inducible factor (HIF-1α), which is an essential transcription factor activated in hypoxic environments, plays a vital role in vascular network construction. HIF-1α, which plays a central role in regulating cartilage and bone formation, induces vascular invasion and differentiation of osteoprogenitor cells to promote and maintain extracellular matrix production by mediating the adaptive response of cells to changes in oxygen levels. However, the application of HIF-1α in bone tissue engineering is still controversial. As such, clarifying the function of HIF-1α in regulating the bone regeneration process is one of the urgent issues that need to be addressed. This review provides insight into the mechanisms of HIF-1α action in bone regeneration and related recent advances. It also describes current strategies for applying hypoxia induction and hypoxia mimicry in bone tissue engineering, providing theoretical support for the use of HIF-1α in establishing a novel and feasible bone repair strategy in clinical settings.

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Section: Discussionmentioning

confidence: 79%

The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering

You

Zhai

et al. 2023

IJMS

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“…35 However, as a transcription factor, HIF-1ɑ can regulate the expression of a spectrum of angiogenic factors, which mainly affects angiogenesis indirectly by activating target genes related to angiogenesis. 36 Moreover, the skin tissue reaction results in vivo by histological studies was confirmed that with the increase of implantation time, the number of macrophages around the material increased sharply. It can be seen that the increasing gradient of silicon element content did not have a different effect on the number of macrophages, which may be because low concentrations of silicon ions have been able to stimulate the formation of macrophages.…”

Section: Effects Of Pais On Skin Tissue Reaction In Vivomentioning

confidence: 76%

“…Some researches show that VEGF is the principle pro‐angiogenic growth factor participating in the formation of blood vessel 35 . However, as a transcription factor, HIF‐1ɑ can regulate the expression of a spectrum of angiogenic factors, which mainly affects angiogenesis indirectly by activating target genes related to angiogenesis 36 . Moreover, the skin tissue reaction results in vivo by histological studies was confirmed that with the increase of implantation time, the number of macrophages around the material increased sharply.…”

Section: Discussionmentioning

confidence: 95%

The effect of silicon groups on the physicochemical property and bioactivity of L‐phenylalanine derived poly(amide‐imide)

Zhang

Zou

et al. 2023

J Biomed Mater Res

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Poly(amide‐imide) (PAI), serving as a synthetic polymer, has been widely used in industry for excellent mechanical properties, chemical resistance and high thermal stability. However, lack of suitable cell niche and biological activity limited the further application of PAI in biomedical engineering. Herein, silicon modified L‐phenylalanine derived poly(amide‐imide) (PAIS) was synthesized by introducing silica to L‐phenylalanine derived PAI to improve physicochemical and biological performances. The influence of silicon amount on physicochemical, immune, and angiogenic performances of PAIS were systemically studied. The results show that PAIS exerts excellent hydrophilic, mechanical, biological activity. PAIS shows no effects on the number of macrophages, but can regulate macrophage polarization and angiogenesis in a dose‐dependent manner. This study advanced our understanding of silicon modification in PAI can modulate cell responses via initiating silicon concentration regulation. The acquired knowledge will provide a new strategy to design and optimize biomedical PAI in the future.

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“…Hypoxia-inducible factor (HIF)-1, a major and key factor mediating the mammalian hypoxia response, regulates the oxygen balance at the cellular, tissue, and biological levels [39]. Recent studies have shown that HIF-1 signaling pathway, which responds to hypoxic conditions, plays an important role in angiogenesis [40]. Endothelin is a peptide family containing three isoforms, EDN1, EDN2 and EDN3 [41], whose EDN1 can regulate vasoconstriction, affect cell proliferation, differentiation, migration, and apoptosis [42][43].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic study of testicular hypoxia adaptation in Tibetan sheep

Yu,

Yang,

et al. 2024

Preprint

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The Tibetan sheep is a typical hypoxia-tolerant mammal, which lives on the plateau, an altitude of between 2,500 and 5,000 meters above sea level, the study of its hypoxic adaptation mechanism provides reference for exploring the hypoxic adaptation mechanism of other animals. To grope for the genetic mechanism of adaptation to hypoxic environment at the transcriptional level in Tibetan sheep testicular tissue, and to identify candidate genes and key pathways related to sheep adaptation. Histological observation of testicular tissues from two sheep breeds was carried out using hematoxylin-eosin (HE) conventional staining. A total of 277 differentially expressed genes (DEGs) were authenticated at high altitude Tibetan sheep (ZYH) and low altitude Tibetan sheep (ZYM) by RNA sequencing technology (RNA-Seq), which included 165 up-regulated genes and 112 down-regulated genes. Functional analyses revealed several terms and pathways, such as were closely related with testis adaptation to plateau. Several genes (includingGGT5, AGTR2, EDN1, LPAR3, CYP2C19, IGFBP3, APOC3andPKC1) were remarkably enriched in several pathways and terms, which may impact the Plateau adaptability of sheep by adjusting its reproductive activity and sexual maturation, and protecting Sertoli cells, various spermatocytes and spermatogenesis processes. The results make a reasonable case for a better understanding of the molecular mechanisms of adaptation to altitude in sheep.

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Hypoxia inducible factor-1 signaling pathway in macrophage involved angiogenesis in materials-instructed osteo-induction

Abstract: Although osteo-inductive materials are regarded as promising candidates for critical-sized bone repair, their clinical application is limited by ambiguous mechanisms. The hypoxia-inducible factor (HIF)-1 signaling pathway, which responds to hypoxic...

Cited by 5 publications

References 68 publications

The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering

The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering

The effect of silicon groups on the physicochemical property and bioactivity of L‐phenylalanine derived poly(amide‐imide)

Transcriptomic study of testicular hypoxia adaptation in Tibetan sheep

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