2014
DOI: 10.1523/jneurosci.4590-13.2014
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Hypoxia Inducible Factor-1α (HIF-1α) Is Required for Neural Stem Cell Maintenance and Vascular Stability in the Adult Mouse SVZ

Abstract: HIF-1␣ is a hypoxia-inducible protein that regulates many cell and molecular processes, including those involved in angiogenesis and

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Cited by 69 publications
(62 citation statements)
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“…Dependence on VEGF could similarly be a cell-intrinsic difference between these two populations. Potentially in contrast to these and previous findings (16), however, a recent study suggests that SVZ progenitors may require HIF1α, a transcriptional regulator of VEGF and several other hypoxia-related genes, to maintain their vascular niche (56). Further studies will therefore be necessary to determine fully the quantity and contribution of NSPC-derived VEGF in the SVZ neurogenic niche.…”
Section: Vehiclementioning
confidence: 60%
“…Dependence on VEGF could similarly be a cell-intrinsic difference between these two populations. Potentially in contrast to these and previous findings (16), however, a recent study suggests that SVZ progenitors may require HIF1α, a transcriptional regulator of VEGF and several other hypoxia-related genes, to maintain their vascular niche (56). Further studies will therefore be necessary to determine fully the quantity and contribution of NSPC-derived VEGF in the SVZ neurogenic niche.…”
Section: Vehiclementioning
confidence: 60%
“…Increasing evidence suggests that the tumorigenic process in GB is apparently initiated and maintained by a rare and special subpopulation of slow-cycling clonogenic cells referred to as GSCs [28,62,66,67]. It has been assumed that overall survival heterogeneity [33,45,46] in patients with GB might be related to GSCs variability and brain microenvironment [58]. Presently, it is not clear what the origin of GSCs is, but presumably it may arise from SVZ stem cells.…”
Section: Glioblastoma Stem Cells and Ykl-40mentioning
confidence: 99%
“…source of new neurons in the adult brain, and contains a subset of astrocytes which behave as stem cells both in vivo and in vitro [18,25,30,43,45,68], and derive from radial glia (RG) cells [17,39]. In fact, RG cells also act as NSCs and source of neurogenesis, and probably give rise to astrocytes in the cerebral cortex [17,23,64,74].…”
mentioning
confidence: 99%
“…Hypoxic signaling plays an important role in the differentiation and development of NSCs [17]. Previous studies have identified that hypoxia and hypoxia-inducible factor (HIF)-1α can regulate the proliferation, differentiation, and neuronal maturation of NSCs [18, 19]. HIF-1α is an essential transcriptional regulator of metabolism and angiogenesis, and a previous study suggested that HIF-1α can regulate the fate of NSCs [20].…”
Section: Introductionmentioning
confidence: 99%