2022
DOI: 10.1016/j.jare.2021.10.001
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Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer

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Cited by 144 publications
(88 citation statements)
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“…To further study the influence of dysfunctional SM on the TIME of OS patients and its predictive significance in OS patients, a prognostic model derived from SM-relevant genes was constructed and verified in the validation cohort. In our model, all three genes identified were associated with tumor initiation and progression (26)(27)(28). CBS encodes a homotetrameric enzyme that catalyzes the first step in the transsulfuration pathway and converses the homocysteine to cystathionine, which is associated with various stomach, liver, and ovarian cancers and influences immune evasion (29).…”
Section: A B D Cmentioning
confidence: 97%
“…To further study the influence of dysfunctional SM on the TIME of OS patients and its predictive significance in OS patients, a prognostic model derived from SM-relevant genes was constructed and verified in the validation cohort. In our model, all three genes identified were associated with tumor initiation and progression (26)(27)(28). CBS encodes a homotetrameric enzyme that catalyzes the first step in the transsulfuration pathway and converses the homocysteine to cystathionine, which is associated with various stomach, liver, and ovarian cancers and influences immune evasion (29).…”
Section: A B D Cmentioning
confidence: 97%
“…LncRNA-PMAN was upregulated in GC cells and inhibited Erastin-and RSL3-induced ferroptosis, leading to poor prognosis and peritoneal metastasis [22]. A hypoxia-induced lncRNA-CBSLR could protect GC cells from ferroptosis, which could contribute to chem-resistance in GC patients [23].…”
Section: Clinical Outcomes and Potential Therapies Prediction Of Subg...mentioning
confidence: 99%
“…LncRNA-PMAN was upregulated in GC cells and inhibited Erastin- and RSL3-induced ferroptosis, leading to poor prognosis and peritoneal metastasis [ 22 ]. A hypoxia-induced lncRNA-CBSLR could protect GC cells from ferroptosis, which could contribute to chem-resistance in GC patients [ 23 ]. Considering the tight relationship among ferroptosis, lncRNA, and GC, we constructed a molecular signature based on the ferroptosis-related lncRNAs (FRLs) for GC patients in this study, aiming to help the prognosis prediction of GC.…”
Section: Introductionmentioning
confidence: 99%
“…4-HNE is currently considered a major bioactive marker of lipid peroxidation and a signalling molecule involved in the regulation of transcription factors sensitive to stress, such as nuclear factor erythroid 2-related factor 2 (Nrf2), in cell proliferation, differentiation, and death [ 25 ]. In ferroptosis, MDA and 4-HNE are reliable markers of oxidative stress-induced lipid peroxidation in cancer [ 28 ], AD [ 29 ], and acute lung injury [ 30 ].…”
Section: Main Characteristics Of Ferroptosismentioning
confidence: 99%