Hypoxia ischemia affects ultrasonic vocalization in the neonatal rat

Saucier, Deborah M.; Ehresman, Crystal; Keller, Avril J.; Armstrong, Edward A.; Elderkin, Amber; Yager, Jerome Y.

doi:10.1016/j.bbr.2008.02.025

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…It is essential to highlight the reduction in the mean and total duration of USV only in the MA group; this may be related to the increase in the number of calls in the group when considering the peak of quantification of 40 kHz USVs between P7 and P9 [23, 25, 40, 68]. Contrary to Saucier et al [39], who used a different experimental paradigm, their ischemic pups presented fewer USVs than control pups; male ischemic pups experienced a more significant reduction in the quantity of USVs compared to female pups, and we found this reduction only in females’ pups, since male’s pups had an increase in this parameter. Although the relationship between species requires caution, and different physiological apparatuses produce cries of human infants and rat pups, the translational evaluation of infant vocalizations may contribute to a better understanding of the effects of variations in the perinatal environment on infant neurobehavioral development [23, 69, 70].…”

Section: Discussionmentioning

confidence: 97%

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

et al. 2022

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Hypoxic-ischemic encephalopathy is a severe clinical condition, among others, affecting the brain after offspring exposure to neonatal anoxia, which causes persistent sensorimotor and cognitive deficits. During peripartum, maternal behaviors are crucial for the healthy development of the offspring. In rats, the vocalization of newborns, around 40 kHz, corresponds to separation calls that encourage their mothers to retrieve them. Alterations in this pattern affect the maternal behavior addressed to the offspring. This study aimed to evaluate the maternal behavior of primiparous rats whose offspring were exposed to neonatal Anoxia in P2 (postpartum day) during the lactation period, to assess mother-pup interactions through the pups' vocalization from P3 to P18. It also intends to quantify eventual neuronal alterations in the mothers' medial preoptic area (MPOA) after the last weaning (P21) through FOS protein expression. Anoxia offspring were found to reduce maternal behaviors towards them, increased frequency of separation calls in the male anoxia group, and reduced vocalization rate in the female anoxia group compared to their respective controls. Body weight gain reduction of males' and females' anoxia was observed. We concluded that anoxia exerts deleterious effects on the vocalization patterns of the pups, with sex differences that alter maternal behavior towards them. Impaired USV makes an additional negative impact on the already noxious effects of neonatal anoxia. Understanding those phenomena apply/contributes to guiding procedures and strategies to mitigate the deleterious outcomes and orient research concerning the complexity of neonatal anoxia events and the influence of maternal care quality concerning the pups, which should also be considered sex differences.

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Section: Discussionmentioning

confidence: 97%

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

et al. 2022

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“…This review is focused on sexual dimorphism of the rat larynx and USVs; however, sex differences exist in other rodent species' USVs (e.g., hamsters [12] and mice [13][14][15][16]) and sexual dimorphism of USVs is also mediated by sex differences within the central nervous system, not just the larynx [17][18][19]. Nevertheless, the rat model is widely used to study vocal communication in a variety of contexts such as social environment [1,5,7,9,[20][21][22][23], neurogenic disorders [24][25][26][27][28][29], aging [30][31][32][33][34][35], and pharmacology [36][37][38][39][40][41][42][43][44], justifying the need for a comprehensive review of the literature attuned to sex differences.…”

Section: Introductionmentioning

confidence: 99%

Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization

et al. 2021

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The rat model is a useful tool for understanding peripheral and central mechanisms of laryngeal biology. Rats produce ultrasonic vocalizations (USVs) that have communicative intent and are altered by experimental conditions such as social environment, stress, diet, drugs, age, and neurological diseases, validating the rat model’s utility for studying communication and related deficits. Sex differences are apparent in both the rat larynx and USV acoustics and are differentially affected by experimental conditions. Therefore, the purpose of this review paper is to highlight the known sex differences in rat USV production, acoustics, and laryngeal biology detailed in the literature across the lifespan.

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“…These courtship songs have been analyzed for spectrogram patterns and quantity in normal mice, but analysis of chronic changes in vocalization patterns and quantity in males after stroke has not been investigated (19, 20, 21, 22, 23). USVs have also been well characterized in neonatal mice, which vocalize robustly when removed from the dam (24). Similar to the language deficits seen in humans, pups with heterozygous mutations of FOXP2 show deficits in vocalization production (25, 26, 27).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic vocalization changes and FOXP2 expression after experimental stroke

Doran

Trammel

Benashaski

et al. 2015

Behavioural Brain Research

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Speech impairments affect one in four stroke survivors. However, animal models of post-ischemic vocalization deficits are limited. Male mice vocalize at ultrasonic frequencies when exposed to an estrous female mouse. In this study we assessed vocalization patterns and quantity in male mice after cerebral ischemia. FOXP2, a gene associated with verbal dyspraxia in humans, with known roles in neurogenesis and synaptic plasticity, was also examined after injury. Using a transient middle cerebral artery occlusion (MCAO) model, we assessed correlates of vocal impairment at several time-points after stroke. Further, to identify possible lateralization of vocalization deficits induced by left and right hemispheric strokes were compared. Significant differences in vocalization quantity were observed between stroke and sham animals that persisted for a month after injury. Injury to the left hemisphere reduced early vocalizations more profoundly than those to the right hemisphere. Nuclear expression of Foxp2 was elevated early after stroke (at 6 hours), but significantly decreased 24 hours after injury in both the nucleus and the cytoplasm. Neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury. This study demonstrates that quantifiable deficits in ultrasonic vocalizations (USVs) are seen after stroke. USV may be a useful tool to assess chronic behavioral recovery in murine models of stroke.

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Hypoxia ischemia affects ultrasonic vocalization in the neonatal rat

Cited by 13 publications

References 33 publications

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization

Ultrasonic vocalization changes and FOXP2 expression after experimental stroke

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