Hypoxia mediates the decreased sensibility of human lung adenocarcinoma cell H1299 to cisplatin through inducing autophagy

Jin, Chao-chao; Zhang, Shuping; Jiang, Yuan; Wang, Xuelei; Jin, Nuo; Huang, Jiuning

doi:10.23736/s0026-4733.17.07472-7

Minerva Surg

2018

DOI: 10.23736/s0026-4733.17.07472-7

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Hypoxia mediates the decreased sensibility of human lung adenocarcinoma cell H1299 to cisplatin through inducing autophagy

Chao-chao Jin

Shuping Zhang

Yuan Jiang

et al.

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miR-503 suppresses the proliferation and metastasis of esophageal squamous cell carcinoma by triggering autophagy via PKA/mTOR signaling

Gao

et al. 2018

Int J Oncol

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MicroRNA (miR)-503 is involved in the regulation of the malignant phenotype in multiple tumor types, and has been proven to be a novel diagnostic and therapeutic target; however, its function and mechanisms of action have not yet been fully elucidated in esophageal squamous cell carcinoma (ESCC). In the current study, we detected miR-503 expression by RT-qPCR and found that miR-503 expression was increased in ESCC, but negatively correlated with lymph node metastasis, TNM stage and tumor differentiation. Functionally, we confirmed that miR-503 inhibited the proliferation and metastasis of ESCC cells by triggering cellular autophagy. Mechanistically, we confirmed that miR-503 exerted its biological effects by targeting protein kinase CAMP-activated catalytic subunit alpha (PRKACA) in ESCC by dual luciferase reporter assay. Moreover, miR-503 was found to trigger autophagy in ESCC cells through the protein kinase A (PKA)/mammalian target of rapamycin (mTOR) pathway. Taken together, our results demonstrate that miR-503 suppresses the proliferation and metastasis of ESCC via the activation of autophagy, mediated by the PKA/mTOR signaling pathway.

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miR-503 suppresses the proliferation and metastasis of esophageal squamous cell carcinoma by triggering autophagy via PKA/mTOR signaling

Gao

et al. 2018

Int J Oncol

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Hypoxia mediates the decreased sensibility of human lung adenocarcinoma cell H1299 to cisplatin through inducing autophagy

Cited by 1 publication

References 0 publications

miR-503 suppresses the proliferation and metastasis of esophageal squamous cell carcinoma by triggering autophagy via PKA/mTOR signaling

miR-503 suppresses the proliferation and metastasis of esophageal squamous cell carcinoma by triggering autophagy via PKA/mTOR signaling

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