2020
DOI: 10.1186/s13046-020-01639-2
|View full text |Cite
|
Sign up to set email alerts
|

Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas

Abstract: Radiotherapy is the cornerstone of treatment of high-grade gliomas (HGGs). It eradicates tumor cells by inducing oxidative stress and subsequent DNA damage. Unfortunately, almost all HGGs recur locally within several months secondary to radioresistance with intricate molecular mechanisms. Therefore, unravelling specific underlying mechanisms of radioresistance is critical to elucidating novel strategies to improve the radiosensitivity of tumor cells, and enhance the efficacy of radiotherapy. This review addres… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
35
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 33 publications
(36 citation statements)
references
References 163 publications
(197 reference statements)
1
35
0
Order By: Relevance
“…From the data reviewed, it follows that the radiosensitization of hypoxia-adapted cancer cells is not a simple problem at all, because, in vivo, too many various factors may somehow affect the outcome of radiotherapy, even including a factor such as the circadian rhythm [ 57 ]. The authors of the review believe it is important that the stress-responsive formation of a hypoxia-resistant cancer cell phenotype (and a CSC-like phenotype) occurring in poorly vascularized tumor regions or in microsphere-embolized tumors is accompanied by the enhancement of tumor radioresistance.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…From the data reviewed, it follows that the radiosensitization of hypoxia-adapted cancer cells is not a simple problem at all, because, in vivo, too many various factors may somehow affect the outcome of radiotherapy, even including a factor such as the circadian rhythm [ 57 ]. The authors of the review believe it is important that the stress-responsive formation of a hypoxia-resistant cancer cell phenotype (and a CSC-like phenotype) occurring in poorly vascularized tumor regions or in microsphere-embolized tumors is accompanied by the enhancement of tumor radioresistance.…”
Section: Discussionmentioning
confidence: 99%
“…Such a switching is largely based on the HIF-1-dependent expression of key enzymes and regulators of carbohydrate metabolism and leads to the decrease in producing reactive oxygen species (ROS) and intracellular accumulation of reduced glutathione (GSH); all this potentiates both the antioxidant capacity of hypoxic tumor cells and their radioresistance (see Figure 4 and Figure 5 and Section 3 ). Interestingly, the HIF-1 signaling pathway is a targetable link between the cellular metabolism, circadian rhythm, DNA repair and response to radiotherapy in high-grade gliomas (reviewed in [ 57 ]).…”
Section: Hypoxia-inducible Factors: Their Regulation and Contributmentioning
confidence: 99%
See 1 more Smart Citation
“…Hypoxia can promote the proliferation, invasion and migration of tumors through upregulation of HIF-1 ( 27 ). HIF-1 is the key transcription factor under hypoxia and is involved in the malignant phenotype of ovary cancers ( 28 ). For example, HIF-1 mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells ( 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…Hypoxia can promotethe proliferation, invasion and migration of tumors through upregulation of HIF-1 [27]. HIF-1 is the key transcription factor under hypoxia and is involved in the malignant phenotype of ovary cancers [28]. For example, HIF-1 mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells [29].…”
Section: Discussionmentioning
confidence: 99%