Hypoxia regulates CD9 expression and dissemination of B lymphoblasts

Rouger-Gaudichon, Jérémie; Cousin, Élie; Jakobczyk, Hélène; Debaize, Lydie; Rio, Anne-Gaëlle; Forestier, Anne; Arnaud, Marie-Pierre; Villacreces, Arnaud; Perreten, Vincent; Jácamo, Rodrigo; Galibert, Marie‐Dominique; Troadec, Marie‐Bérengère; Gandemer, Virginie

doi:10.1016/j.leukres.2022.106964

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“…It has been reported that hypoxia Inducible Factor 1α (HIF1α), the master transcription factor involved in hypoxia response, bind directly CD9 promoter and induce CD9 transcription in leukemic cells. 16 We stimulated Ang II after knocking down HIF1α in NRCMs, and found that knocking down HIF1α could abolish the promoting effect of Ang II on CD9 expression ( Figure 1 H). In addition, we constructed a CD9 promoter reporter plasmid with hypoxia responsive elements (HRE) mutated.…”

Section: Resultsmentioning

confidence: 90%