Hypoxiaâischaemia is involved in the pathogenesis of vulvar lichen sclerosus

Li, Y.-Z.; Wu, Ying; Zhang, Q.-H.; Wang, Y.; Zhen, Junhui; Li, S.-L.

doi:10.1111/j.1365-2230.2009.03571.x

Cited by 8 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypoxia, ischemia, and vascular damage are due to increased GLUT1 and decreased vascular endothelial growth factor (GF) expression in affected skin. [5] The effect of cell-mediated cytotoxicity has also been defined. [6] Although many authors have described LS and scleroderma as closely related entities or even their associations have been seen, there is no systemic involvement in LSA.…”

Section: Pathophysiologymentioning

confidence: 99%

Vulvar lichen sclerosus et atrophicus

Nair

2017

J Mid-life Health

View full text Add to dashboard Cite

Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Thinning and shrinkage of the genital area make coitus, urination, and defecation painful. LS is not uncommon in India and present as an itchy vulvar dermatosis which a gynecologist may mistake for candidal vulvovaginitis. There is often a delay in diagnosis of VLS due to its asymptomatic nature and lack of awareness in patients as well as physicians. Embarrassment of patients due to private nature of the disease and failure to examine the genital skin properly are the other reasons for delay in diagnosis. There is no curative treatment for LS. Various medications available only relieve the symptoms. Chronic nature of the disease affects the quality of life. Proper and regular follow-up is required as there are chances of the development of squamous cell carcinoma.

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Vulvar lichen sclerosus et atrophicus

Nair

2017

J Mid-life Health

View full text Add to dashboard Cite

show abstract

“…Sander et al demonstrated that lesional skin showed lipid peroxidation of epidermal basal cell layers, oxidative DNA damage, and oxidative protein damage. The finding of high glut‐1 and low vascular endothelial growth factor (VEGF) expression in affected skin supports the theory that hypoxia and ischemia play a role in LS . Local factors such as trauma, sunburn, and radiation may also contribute.…”

Section: Discussionmentioning

confidence: 59%

Association Between Lichen Sclerosus and Celiac Disease: A Report of Three Pediatric Cases

Jacobs

Gilliam

Khavari

et al. 2014

Pediatric Dermatology

View full text Add to dashboard Cite

The prevalence of celiac disease (CD) is increasing and may be as high as 1% of the US population. The typical presentation of CD generally includes gastrointestinal symptoms, but more individuals are presenting with extraintestinal manifestations. A wide variety of dermatologic associations have been described with CD, including alopecia, dermatitis herpetiformis, and enamel hypoplasia. In this report we describe three girls with CD who presented with hypopigmented skin lesions and pruritus in the perivaginal and perianal areas, consistent with the diagnosis of lichen sclerosus (LS). All three presented within 1 year to the same practitioner. To our knowledge, this association has not previously been explored in the literature. These cases elucidate a possible relationship between CD and LS.

show abstract

“…Regarding the cutaneous vascular structures, there is damage of the vascular endothelium and capillaries, and disruptions of the capillary morphology. Hypoxia markers were suggestive of hypoxia involvement in the VLS pathogenesis (39) .…”

Section: Gineco Eumentioning

confidence: 97%

Vulvar lichen sclerosus, premalign inflammatory dermatosis

Rotaru¹

2015

Gineco.eu

View full text Add to dashboard Cite

Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition classified as precancerous dermatosis of the genital mucosa, associated with a risk of progression to in situ, then invasive vulvar squamous cell carcinomas. Although the etiology of this disease has not been determined, the factors involved in its pathogenesis are genetic, autoimmune, hormonal, infectious as well as environmentally-mediated. Given the risk of malign progression, these type of skin lesions have to be carefully watched by regular clinical exams, and a biopsy of the affected genital mucosa should be carried out whenever dysplasia or malign transformation is suspected. Vulvar carcinogenesis is a multistage process, regardless of the type (i.e. differentiated or not) of intraepithelial vulval neoplasia (IVN), which includes human papilloma viruses (HPV)-negative immune-mediated inflammatory disease, mainly the VLS. The involvement of HPV as main trigger in IVN has been clearly confirmed. The present paper comprises a synthetic review of the available literature on this borderline type of disease referred to as VLS, and looks at the mainly clinical and diagnostic aspects that need to be observed by the clinicians. Considering the potential for progression of the disease, it is of foremost importance to diagnose VLS in an early stage, to closely follow up with the gynecologist and dermatologist, while carefully and steadily monitoring these lesions and to initiate the appropriate disease-specific treatment.

show abstract

Hypoxiaâischaemia is involved in the pathogenesis of vulvar lichen sclerosus

Abstract: HI is involved in the pathogenesis of vulvar LS.

Cited by 8 publications

References 16 publications

Vulvar lichen sclerosus et atrophicus

Vulvar lichen sclerosus et atrophicus

Association Between Lichen Sclerosus and Celiac Disease: A Report of Three Pediatric Cases

Vulvar lichen sclerosus, premalign inflammatory dermatosis

Contact Info

Product

Resources

About

Hypoxiaâischaemia is involved in the pathogenesis of vulvar lichen sclerosus

Abstract: HI is involved in the pathogenesis of vulvar LS.

Cited by 8 publications

References 16 publications

Vulvar lichen sclerosus et atrophicus

Vulvar lichen sclerosus et atrophicus

Association Between Lichen Sclerosus and Celiac Disease: A Report of Three Pediatric Cases

Vulvar lichen sclerosus, premalign inflammatory dermatosis

Contact Info

Product

Resources

About

Hypoxiaâischaemia is involved in the pathogenesis of vulvar lichen sclerosus