Hypoxic Breast Cancer Cell-Derived Exosomal SNHG1 Promotes Breast Cancer Growth and Angiogenesis via Regulating miR-216b-5p/JAK2 Axis

Dai, Gaosai; Yang, Yupeng; Liu, Shuhao; Liu, Huantao

doi:10.2147/cmar.s327621

Cited by 22 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiR-210 was involved in the expression of vascular remodeling related genes, such as Ephrin A3 and PTP1B, which function to promote angiogenesis ( 59 ). In addition to miR-210, lncRNA SNHG1, which was enriched in the hypoxic breast cancer cells secreted exosomes, also promoted the angiogenesis, as well as the proliferation and migration of HUVECs ( 60 ). And some research indicated that hypoxic exosomes were preferentially taken up by hypoxic cancer cells ( 191 ).…”

Section: Hypoxic Exosomes Promote the Development Of Different Types ...mentioning

confidence: 99%

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

et al. 2022

View full text Add to dashboard Cite

Exosomes are small extracellular vesicles that are secreted by almost all types of cells and exist in almost all extracellular spaces. As an important mediator of intercellular communication, exosomes encapsulate the miRNA, lncRNA, cirRNA, mRNA, cytokine, enzyme, lipid, and other components from the cytoplasm into its closed single membrane structure and transfer them to recipient units in an autocrine, paracrine, or endocrine manner. Hypoxia is a state of low oxygen tension and is involved in many pathological processes. Hypoxia influences the size, quantity, and expression of exosome cargos. Exosomes derived from hypoxic tumor cells transfer genetics, proteins, and lipids to the recipient units to exert pleiotropic effects. Different donor cells produce different cargo contents, target different recipient units and lead to different biological effects. Hypoxic exosomes derived from tumor cells uptaken by normoxic tumor cells lead to promoted proliferation, migration, and invasion; uptaken by extracellular space or liver lead to promoted metastasis; uptaken by endothelial cells lead to promoted angiogenesis; uptaken by immune cells lead to promoted macrophage polarization and changed tumor immune microenvironment. In addition to various types of tumors, hypoxic exosomes also participate in the development of diseases in the cardiovascular system, neuron system, respiratory system, hematology system, endocrine system, urinary system, reproduction system, and skeletomuscular system. Understanding the special characteristics of hypoxic exosomes provide new insight into elaborating the pathogenesis of hypoxia related disease. This review summarizes hypoxia induced cargo changes and the biological effects of hypoxic exosomes in tumors and non-malignant diseases in different systems.

show abstract

Section: Hypoxic Exosomes Promote the Development Of Different Types ...mentioning

confidence: 99%

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Among them, miR-139-5p was reported to interact with SNHG3 in gastric cancer [ 62 ], clear cell renal cell carcinoma [ 64 ], ovarian cancer [ 65 ], and HCC [ 66 ]. SNHG1 sponged miR-216b-5p to promote cell growth and migration in serous epithelial ovarian cancer [ 67 ] and promote tumor angiogenesis and growth in breast cancer [ 68 ]. These findings provide further confirmation that SNHG1 and SNHG3 affect HCC cell behaviors through miRNAs.…”

Section: Resultsmentioning

confidence: 99%

Identification of m6A-Related lncRNA to Predict the Prognosis of Patients with Hepatocellular Carcinoma

Wang

2022

BioMed Research International

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In the past decades, HCC treatment has achieved great progress; however, the overall prognosis remains poor. Therefore, it is the need of the hour to identify new prognostic biomarkers which can advance our understanding related to the underlying molecular mechanism of adverse prognosis and apply them to clinical work in prognosis prediction. In the present study, data of 576 HCC patients and 292 normal control cases from TCGA and ICGC databases were enrolled to our bioinformatic analysis. SNHG1 and SNHG3 were identified as overlapping genes in TCGA and ICGC databases using Pearson correlation analysis and univariate Cox regression analysis. Further, we used the median of the SNHG1 and SNHG3 expression values as the cutoff values to define the HCC patient groups with high or low expression level. The subsequent analysis revealed that abnormal high expression of SNHG1 or SNHG3 affected the immune infiltration patterns and the crosstalk among immune cells. Moreover, high expression of SNHG1 or SNHG3 resulted in drug resistant to AKT inhibitor VII, bexarotene, bicalutamide, dasatinib, erlotinib, and gefitinib. In addition, lower tumor neoantigen burden was observed in high SNHG1 or SNHG3 group. Further, we found significant relation between the aberrant upregulation of SNHG1 and SNHG3 in tumor grade and stage. We established a nomogram to systematically predict the 5- and 8-year overall survival of liver cancer patients with good accuracy. Finally, the in vitro assays suggest that SNHG1 and SNHG3 promote the proliferative, migratory, and invasive abilities of HCC cells.

show abstract

“…[174,181,197] Among these lncRNAs, NORAD, OIP5-AS1, ARSR, SNHG1, and ATB were upregulated in skeletal, urinary, and reproductive system tissues and facilitated cancer development. [175,224,226,239,225] In contrast, the remaining nine lncRNAs (GAS5, LINC01915, LINC00662, FAM225A, SNHG16, LINC00161, SNHG11, CCAT1, and UCA1), GAS5 with LINC01915 were downregulated in respiratory and colorectal cancer, [180,213] the left were upregulated in digestive cancer tissues and promoted oesophageal adenocarcinoma, hepatocellular and pancreatic cancer progression. [187,190,196,201,236,237,248] It is well documented that EVs and miRNAs are irreplaceable intercellular communication tools and have received great attention due to their modulation of angiogenesis.…”

Section: Ev-associated Ncrna-based Regulation Of Cancer-related Angio...mentioning

confidence: 99%

Extracellular Vesicles as Delivery Shippers for Noncoding RNA‐Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer

Pan

Liu

Wei

et al. 2023

Small

View full text Add to dashboard Cite

Ischemic stroke and systemic cancer are two of the leading causes of mortality. Hypoxia is a central pathophysiological component in ischemic stroke and cancer, representing a joint medical function. This function includes angiogenesis regulation. Vascular remodeling coupled with axonal outgrowth following cerebral ischemia is critical in improving poststroke neurological functional recovery. Antiangiogenic strategies can inhibit cancer vascularization and play a vital role in impeding cancer growth, invasion, and metastasis. Although there are significant differences in the cause of angiogenesis across both pathophysiological conditions, emerging evidence states that common signaling structures, such as extracellular vesicles (EVs) and noncoding RNAs (ncRNAs), are involved in this context. EVs, heterogeneous membrane vesicles encapsulating proteomic genetic information from parental cells, act as multifunctional regulators of intercellular communication. Among the multifaceted roles in modulating biological responses, exhaustive evidence shows that ncRNAs are selectively sorted into EVs, modulating common specific aspects of cancer development and stroke prognosis, namely, angiogenesis. This review will discuss recent advancements in the EV‐facilitated/inhibited progression of specific elements of angiogenesis with a particular concern about ncRNAs within these vesicles. The review is concluded by underlining the clinical opportunities of EV‐derived ncRNAs as diagnostic, prognostic, and therapeutic agents.

show abstract

Hypoxic Breast Cancer Cell-Derived Exosomal SNHG1 Promotes Breast Cancer Growth and Angiogenesis via Regulating miR-216b-5p/JAK2 Axis

Cited by 22 publications

References 41 publications

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects

Identification of m6A-Related lncRNA to Predict the Prognosis of Patients with Hepatocellular Carcinoma

Extracellular Vesicles as Delivery Shippers for Noncoding RNA‐Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer

Contact Info

Product

Resources

About