2023
DOI: 10.1101/2023.10.04.558359
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Hypoxic injury triggers maladaptive repair in human kidney organoids

Ana B. Nunez-Nescolarde,
Mehran Piran,
Laura Perlaza-Jiménez
et al.

Abstract: Acute kidney injury (AKI) is a common clinical disorder linked to high rates of illness and death. Ischemia is a leading cause of AKI, which can result in chronic kidney disease (CKD) through a maladaptive repair process characterised by failed epithelial regeneration, inflammation, and metabolic dysregulation. No targeted therapies exist to prevent the AKI to CKD transition and insight into ischemic AKI and maladaptive repair in humans remains limited. In this study, we report that human kidney organoids reca… Show more

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