Hypoxic-ischemic encephalopathy: Correlation of serial MRI and outcome

Belet, Nurşen; Belet, Ümit; İncesu, Lütfi; Uysal, Serap; Özinal, Satılmış; Keskin, Tülay; Sünter, Ahmet Tevfik; Küçüködük, Şükrü

doi:10.1016/j.pediatrneurol.2004.04.011

Cited by 74 publications

(63 citation statements)

References 20 publications

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“…Previous long-term follow-up studies suggest that survivors of neonatal encephalopathy without major disability typically have an increased risk of subtle neurological disabilities when they are assessed at school age. In contrast, consistent with the present study, severe disability diagnosed early in life is persistent (7)(8)(9)(10), and the severity of disability appears to be proportional to the severity of neural injury in the neonatal period and in childhood (11,12). For example, in one cohort of 53 children born at term with encephalopathy, 36% had cerebral palsy; of the 34 remaining infants, at school age 8 (15%) had minor neurological dysfunction and/or perceptual-motor WeeFIM ratings as a function of outcome at 18 mo of age.…”

Section: Discussionsupporting

confidence: 90%

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

et al. 2011

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Section: Discussionsupporting

confidence: 90%

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

et al. 2011

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“…Periventricular leukomalacia found in preterms mainly affect the parietal and occipital periventricular white matter and therefore the area of the posterior part of the CC is especially reduced (16,25). In contrast, full-term infants with NE show more widespread and different patterns of cerebral lesions, like watershed injury and/or involvement of the deep gray nuclei (7)(8)(9)(10). These patterns can explain the more diffuse involvement of the CC (26).…”

Section: Van Kooij Et Almentioning

confidence: 99%

“…Long-term follow-up data of neurodevelopmental outcome are still scarce but have shown significantly more problems at school age in children with moderate NE (NE II) according to the criteria of Sarnat (2) compared with children with mild NE according to the criteria of Sarnat (NE I) and matched controls (3)(4)(5)(6). Magnetic resonance imaging (MRI) studies have made a major contribution to recognize the different patterns of NErelated cerebral lesions, which have been shown to be predictive of long-term neurodevelopmental outcome (7)(8)(9)(10).…”

mentioning

confidence: 99%

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

et al. 2008

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ABSTRACT:Magnetic resonance imaging studies have contributed to recognize the patterns of cerebral injury related to neonatal encephalopathy (NE). We assessed whether a smaller corpus callosum (CC) explained the difference in motor performance between school-age children with NE and controls. Frontal, middle, and posterior areas of the CC were measured in 61 9 -10-y-old children with NE and in 47 controls. Motor performance was determined using the Movement Assessment Battery for Children (M-ABC). Linear regression was used to assess whether differences in M-ABC between NE children and controls could be explained by CC size. The CC of 11/30 children with NE type I according to Sarnat (NE I) and 19/36 children with NE type II according to Sarnat (NE II) showed generalized or focal thinning, compared with 8/49 controls. Children with NE II had significantly smaller middle and posterior parts and total areas of the CC. Children with NE scored significantly worse on the M-ABC than controls. The reduction in size of the posterior part of the CC partly explained the mean differences on the M-ABC. Children with NE have poorer motor skills than controls, which is partly explained by a smaller size of the CC. N eonatal encephalopathy (NE) related to perinatal asphyxia has a prevalence of 1-6/1000 live-born, full-term infants (1). Long-term follow-up data of neurodevelopmental outcome are still scarce but have shown significantly more problems at school age in children with moderate NE (NE II) according to the criteria of Sarnat (2) compared with children with mild NE according to the criteria of Sarnat (NE I) and matched controls (3-6). Magnetic resonance imaging (MRI) studies have made a major contribution to recognize the different patterns of NErelated cerebral lesions, which have been shown to be predictive of long-term neurodevelopmental outcome (7-10).The corpus callosum (CC) links associative areas of the two cerebral hemispheres. The genu of the CC is formed between 8 and 13 wk of gestation. After 20 wk gestational age the total CC is formed (11). The CC is among the last structures to be completed during postnatal maturation. Its size increases with age until early adulthood because of the ongoing myelinization process, which begins to appear at about 4 mo of age in the splenium and at 6 mo in the genu (12,13). Due to its longer myelogenetic cycle, the CC is vulnerable to hemorrhage and ischemia (14). Fibers from the frontal lobe and the anterior part of the parietal lobe course through the rostrum and genu of the CC. Fibers from the temporal, posterior part of the parietal and occipital lobe are carried in the caudal portion of the body of the CC and in the splenium (14,15).Several studies have shown a relation between the CC size and motor outcome in preterm infants (16 -18). Maneru et al. (19) demonstrated that the CC was smaller in adolescents who suffered from moderate asphyxia than in controls. The CC measurements correlated with neuropsychological performance.In the present study, we assessed the differ...

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“…Other studies have found a neuroimaging correlation with neurodevelopmental prognosis, with deep gray matter involvement on MR imaging, encephalomalacia, or periventricular leukomalacia indicating a poor prognosis, 53 and normal neuroimaging indicating a favorable neurodevelopmental outcome 35 Diffusion-weighted MR imaging (which identifies cytotoxic edema in acute ischemia and several other conditions) 426 and diffusion tensor imaging (which depicts the three dimensional structure of the optic radiation) 408 may provide valuable adjunctive information regarding mechanism of injury and anatomical integrity of the optic radiations.…”

Section: Diagnostic and Prognostic Considerationsmentioning

confidence: 94%

“…204 Arteryto-vein and vein-to-vein anastomoses are most problematic. 53 The shunting of blood from one fetus to the other results in diminished size of the donor fetus. An increasing difference in size of the fetuses eventually becomes apparent.…”

Section: Twin Pregnancymentioning

confidence: 99%

The Apparently Blind Infant

Brodsky

2009

Pediatric Neuro-Ophthalmology

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Hypoxic-ischemic encephalopathy: Correlation of serial MRI and outcome

Cited by 74 publications

References 20 publications

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

Corpus Callosum Size in Relation to Motor Performance in 9- to 10-Year-Old Children with Neonatal Encephalopathy

The Apparently Blind Infant

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