2018
DOI: 10.3892/ijmm.2018.3810
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Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Abstract: The unique hypoxic inflammatory microenvironment observed in the spinal cord following spinal cord injury (SCI) limits the survival and efficacy of transplanted bone mesenchymal stem cells (BMSCs). The aim of the present study was to determine whether hypoxic preconditioning (HP) increased the therapeutic effects of BMSC on SCI. BMSCs were pretreated with cobalt chloride (CoCl2) in vitro, and the proliferative apoptotic and migratory abilities of these hypoxic BMSCs (H-BMSCs) were assessed. BMSCs and H-BMSCs d… Show more

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Cited by 23 publications
(37 citation statements)
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“…(Golden et al, 2007;Hill et al, 2010). The improvement of transplant survival achieved with HIF SCs is similar to that observed in some studies (Theus et al, 2008;Wang et al, 2018) in which HIF-1 is targeted in either neural stem cell/progenitor cell or BMSC transplants.…”
Section: Elevation Of Hif In Scs Via Retroviral Expression Of Vp16 Hisupporting
confidence: 80%
See 1 more Smart Citation
“…(Golden et al, 2007;Hill et al, 2010). The improvement of transplant survival achieved with HIF SCs is similar to that observed in some studies (Theus et al, 2008;Wang et al, 2018) in which HIF-1 is targeted in either neural stem cell/progenitor cell or BMSC transplants.…”
Section: Elevation Of Hif In Scs Via Retroviral Expression Of Vp16 Hisupporting
confidence: 80%
“…Recently, hypoxic preconditioning was shown to protect BMSC transplants in the injured spinal cord (Wang et al, 2018). HIF-1 regulates the transcription of more than 100 targets, including key mediators of angiogenesis and tissue vascularization (e.g., VEGF) (Forsythe et al, 1996;Ryan et al, 1998) and glycolysis and glucose metabolism (e.g., enolase) (Semenza et al, 1994;Semenza et al, 1996).…”
Section: Hif-1 Protects Scs From Oxidative Stress and Enhances Transpmentioning
confidence: 99%
“…Thus, finding alternative approaches and exploration of the mechanisms underlying BMSCs in SCI is urgently required. Recent data are mentioned that hypoxia preconditioning, genetic modification, and improving host tissue environment can improve the survival of engrafted cells 810 . Indeed, the stem cell-based therapies for SCI have been widely studied.…”
Section: Introductionmentioning
confidence: 99%
“…It is known that the adult CNS, especially the injured CNS, may provide a relatively non-permissive environment for transplanted MSCs and other stem cells [43,53,54]. Even under the best circumstances, cell survival in injured CNS has been estimated to be less than 10% [43,55,56]. In our study, therefore, with increasing time post-transplantation, the number of transplanted MSCs-GFP-Luci gradually decreased, and few could survive on d 14 (Fig.…”
Section: Discussionmentioning
confidence: 60%