2012
DOI: 10.1016/j.ijrobp.2011.05.037
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Hypoxic Prostate/Muscle Po2 Ratio Predicts for Outcome in Patients With Localized Prostate Cancer: Long-Term Results

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Cited by 76 publications
(66 citation statements)
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“…They found the level of tumour to muscle pO 2 was a strong predictor of prognosis. 25,27,87,89,90 All of the studies listed in Table 2 have shown that a patient had a markedly poorer prognosis when their tumour was more hypoxic. It is likely that these patients will have a larger number of hypoxia-tolerant, more malignant cells free in the circulation and/or already in secondary sites, factors which will impact on recurrence and survival.…”
Section: The Importance Of Tumour Hypoxia On Survival Outcomes Followmentioning
confidence: 99%
“…They found the level of tumour to muscle pO 2 was a strong predictor of prognosis. 25,27,87,89,90 All of the studies listed in Table 2 have shown that a patient had a markedly poorer prognosis when their tumour was more hypoxic. It is likely that these patients will have a larger number of hypoxia-tolerant, more malignant cells free in the circulation and/or already in secondary sites, factors which will impact on recurrence and survival.…”
Section: The Importance Of Tumour Hypoxia On Survival Outcomes Followmentioning
confidence: 99%
“…2 Clinical studies that have attempted to directly measure the level of hypoxia in CaP have used pO 2 electrodes, hypoxia imaging [positron emission tomography (PET)] and immunohistochemistry (IHC) [17][18][19][20][21][22][23][24][25] (Table 1). These studies support the concept that hypoxic subregions exist within localized CaPs and are associated with higher rates of biochemical failure following surgery or RT.…”
Section: Tumour Hypoxia Measurements Are Prognostic In Localized Prosmentioning
confidence: 99%
“…For example, a prospective clinical trial showed that localized CaPs have uptake of the hypoxia biomarker, pimonidazole, and that this uptake correlated with GS but not vascularity. 18 Turaka et al 23 showed that decreased prostate-to-muscle oxygen ratio was an important predictor of early biochemical recurrence following brachytherapy secondary to occult metastases at the time of treatment. In the largest clinical study of CaP hypoxia using direct pO 2 measurements, Milosevic et al 21 showed that hypoxia is associated with both early biochemical relapse and local recurrence in the prostate gland.…”
Section: Tumour Hypoxia Measurements Are Prognostic In Localized Prosmentioning
confidence: 99%
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“…Having established the existence of hypoxia in prostate cancer, Movsas and colleagues went on to show that a low prostate cancer:normal tissue pO 2 ratio was predictive of prostate-specific antigen progression-free survival following brachytherapy treatment [Turaka et al 2012]; however, the number of events (nine) and the total number of patients (57) were relatively small. Also caution must be exercised when interpreting results from electrode studies, as highlighted by Stewart and colleagues [Stewart et al 2010].…”
Section: Hypoxia In Prostate Cancermentioning
confidence: 99%