Hypoxic Pulmonary Vasoconstriction

Dunham‐Snary, Kimberly J.; Wu, Danchen; Sykes, Edward A.; Thakrar, Amar; Parlow, L. R. G.; Mewburn, Jeffrey; Parlow, Joel L.; Archer, Stephen L.

doi:10.1016/j.chest.2016.09.001

Cited by 363 publications

(166 citation statements)

References 89 publications

(71 reference statements)

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“…Poor oxygen supply was a common problem in COPD patients, especially those suffering from acute exacerbations. First, hypoxia caused pulmonary vasoconstriction, 23 which formed pulmonary hypertension, resulting in a right ventricular pressure overload. A study found that NT-proBNP was positively associated with pulmonary arterial pressure.…”

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Role of NT-proBNP for in-Hospital and 1-Year Mortality in Patients with Acute Exacerbations of COPD</p>

Li¹,

Zeng²,

Cheng³

et al. 2020

COPD

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Background and objective: The association between N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations and in-hospital and 1-year mortality in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients is largely unknown. Our objective was to explore the usefulness of NT-proBNP concentrations in AECOPD patients as a prognostic marker for in-hospital and 1-year mortality. Methods: NT-proBNP levels were measured in patients upon admission and laboratory and clinical data were also recorded. The cut-point for the NT-proBNP concentration level for inhospital death was obtained using the receiver operating characteristic (ROC) curve. Univariate and multivariate logistic regression and Cox regression were used in the analyses of factors of inhospital and 1-year mortality. Results: A total of 429 patients were enrolled. Twenty-nine patients died during hospitalization and 59 patients died during the 1-year follow-up. Patients who died in-hospital compared with those in-hospital survivors were older (80.14±6.56 vs 75.93±9.45 years, p=0.003), had a higher percentage of congestive heart failure (65.52% vs 33.75%, p<0.001), had higher NT-proBNP levels (5767.00 (1372.50-12,887.00) vs 236.25 (80.03-1074.75) ng/L, p<0.001), higher neutrophil counts (10.52±5.82 vs 7.70±4.31, p=0.016), higher D-dimer levels (1231.62±1921.29 vs 490.11±830.19, p=0.048), higher blood urea nitrogen levels (9.91±6.33 vs 6.51±4.01 mmol/L, p=0.001), a lower body mass index (19.49±3.57 vs 22.19±4.76, p=0.003), and higher hemoglobin levels (122.34 ±25.36 vs 130.57±19.63, p=0.034). The area under the ROC curve (AUC) for NT-proBNP concentration was 0.88 (95% confidence interval [CI], 0.84-0.93). NT-proBNP concentrations ≥551.35 ng/L were an independent prognostic factor for both in-hospital and 1-year mortality after adjustment for relative risk (RR) (RR=29.54, 95% CI 3.04-286.63, p=0.004 for the multivariate logistic regression analysis) and hazard ratio (HR) (HR=4.47, 95% CI, 2.38-8.41, p <0.001 for the multivariate cox regression analysis). Conclusion: NT-proBNP was a strong and independent predictor of in-hospital and 1-year mortality in AECOPD patients.

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Section: Discussionmentioning

confidence: 99%

<p>Prognostic Role of NT-proBNP for in-Hospital and 1-Year Mortality in Patients with Acute Exacerbations of COPD</p>

Li¹,

Zeng²,

Cheng³

et al. 2020

COPD

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“…This mismatch results in compensatory hypoxic pulmonary vasoconstriction, leading to an inadequate filling of the left atrium. Consequent on this, a decreased left atrial stretch and increased ADH secretion occur (5,10).…”

mentioning

confidence: 91%

COVID-19-associated SIADH: a clue in the times of pandemic!

Yousaf

Al-Shokri

Alsoub

et al. 2020

American Journal of Physiology-Endocrinology and Metabolism

105

102

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“…RV hypertrophy, presumably resulting from hypoxia induced pulmonary vasoconstriction24 leading to persistent pulmonary hypertension, continued into adulthood ( Figure 3). It is well established that hypoxia exposure in the absence of inflammatory lung disease in neonatal rats rapidly leads to RV hypertrophy 15, 25.…”

Section: Discussionmentioning

confidence: 99%

A Translational Model of Incomplete Catch‐Up Growth: Early‐Life Hypoxia and the Effect of Physical Activity

Radom‐Aizik

Zaldivar

Nance

et al. 2018

Clinical Translational Sci

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Advances in therapies have led to prolonged survival from many previously lethal health threats in children, notably among prematurely born babies and those with congenital heart disease. Evidence for catch‐up growth is common in these children, but in many cases the adult phenotype is never achieved. A translational animal model is required in which specific tissues can be studied over a reasonable time interval. We investigated the impact of postnatal hypoxia (HY) (12%O2 (HY12) or 10% O2 (HY10)) on growth in rats relative to animals raised in room air. Subgroups had access to running wheels following the HY period. Growth was fully compensated in adult HY12 rats but not HY10 rats. The results of this study indicate that neonatal hypoxia can be a useful model for the elucidation of mechanisms that mediate successful catch‐up growth following neonatal insults and identify the critical factors that prevent successful catch‐up growth.

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Hypoxic Pulmonary Vasoconstriction

Cited by 363 publications

References 89 publications

<p>Prognostic Role of NT-proBNP for in-Hospital and 1-Year Mortality in Patients with Acute Exacerbations of COPD</p>

<p>Prognostic Role of NT-proBNP for in-Hospital and 1-Year Mortality in Patients with Acute Exacerbations of COPD</p>

COVID-19-associated SIADH: a clue in the times of pandemic!

A Translational Model of Incomplete Catch‐Up Growth: Early‐Life Hypoxia and the Effect of Physical Activity

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