Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition

Do, Myoung‐Sool; Oo, Riabovol; Oo, Ratushna; Oh, Myounghak

doi:10.1515/enr-2017-0002

Cited by 13 publications

(3 citation statements)

References 56 publications

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“…The estrogen receptor antagonist, fulvestrant, was demonstrated to downregulate the IRE1/XBP1 signaling pathway in prolactinoma cells [45]. Conversely, Minchenko et al recently demonstrated that IRE1 inhibition modulates the expression of genes encoding estrogen related proteins in glioma cells [46]. Recent data supports a role for IRE1/XBP1 in glioblastoma development and progression and as such a promising therapeutic target [47,48].…”

Section: Discussionmentioning

confidence: 99%

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

Sansalone

Véliz

Myrthil

et al. 2019

Cancers

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Glioblastoma (GBM) has a dismal prognosis and successful elimination of GBM stem cells (GSCs) is a high-priority as these cells are responsible for tumor regrowth following therapy and ultimately patient relapse. Natural products and their derivatives continue to be a source for the development of effective anticancer drugs and have been shown to effectively target pathways necessary for cancer stem cell self-renewal and proliferation. We generated a series of curcumin inspired bis-chalcones and examined their effect in multiple patient-derived GSC lines. Of the 19 compounds synthesized, four analogs robustly induced GSC death in six separate GSC lines, with a half maximal inhibitory concentration (IC50) ranging from 2.7–5.8 μM and significantly reduced GSC neurosphere formation at sub-cytotoxic levels. Structural analysis indicated that the presence of a methoxy group at position 3 of the lateral phenylic appendages was important for activity. Pathway and drug connectivity analysis of gene expression changes in response to treatment with the most active bis-chalcone 4j (the 3,4,5 trimethoxy substituted analog) suggested that the mechanism of action was the induction of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) mediated cell death. This was confirmed by Western blot analysis in which 4j induced robust increases in CHOP, p-jun and caspase 12. The UPR is believed to play a significant role in GBM pathogenesis and resistance to therapy and as such represents a promising therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

Sansalone

Véliz

Myrthil

et al. 2019

Cancers

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“…Although there were no significant differences in the copy number of some important chromosome fragments like 1p and 19q between two groups, some amplified genes in high IFI30 level like NRIP1 and SSBP2 might participate in the promotion of GBM malignant progression. 16,17 High IFI30 Expression Conferred Chemotherapy Resistance in GBM…”

Section: High Ifi30 Expression-specific Somatic Mutations and Copy Numentioning

confidence: 99%

<p>IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma</p>

Zhu

Chen

Guan

et al. 2020

OTT

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As a crucial part of anti-tumor immunotherapy, interferon-α/β (IFN-α/β) treatment has been broadly applied to clinical trials of glioma. However, less is known about implement of interferon-γ (IFN-γ) in glioma. Further investigating the valuable hub molecular of IFN-γ family might provide us a novel guidance for glioma therapy. Methods: This study carried out an analysis on glioma patients from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts. The analyses were performed by GraphPad Prism 8 and R language. All the validated experiments were performed three times independently. Results: We identified IFI30 as the most stable independent prognostic gene among 20 classical IFN-γ stimulated genes (ISGs) in glioma patients. Furthermore, we found that IFI30 highly expressed in malignant subtypes of glioma and associated with chemotherapy response. We also found IFI30 could activate IL6-STAT6 signal pathway to decline the glioma cells' chemotherapy sensitivity by performing experiments. Gene ontology (GO) analysis showed IFI30 associated with enhanced leucocyte mediated immune and inflammatory response. Microenvironment analysis referred that high IFI30 expression accompanied with more infiltration of M2 type macrophages. Conclusion: IFI30 is involved in the malignant progression and chemotherapy response of glioblastoma, which can be a potential target for treatment in glioblastoma patients.

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“…Еще одним важным фактором, способным регулировать экспрессию эстрогензависимых генов, к которым относят фактор TRIM16, является гипоксия. Показано увеличение его экспрессии в условиях гипоксии на клетках глиомы U87 [19], что считается значимым этапом в развитии опухолей.…”

Section: рис 1 значение Trim16 в развитии злокачественных новообразunclassified

Role of TRIM16 in cancers development

2019

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Тhe protein TRIM16 is involved in key intracellular processes, such as proliferation, cell differentiation and programmed death, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death and immunogenic cell death. The TRIM16 protein acts the proteins TPD43, Gli-1, RARβ, Snail components and MAPK signaling pathway, cadherins, caspases and is also associated with the regulation of the immune system via direct and indirect mechanisms. The influence of TRIM16 protein on the pathogenesis of hormone-dependent tumors is well-known. Further study of the TRIM16 role in the development and progression of malignant neoplasms will form the basis for the development of new methods for predicting the course of the malignant process.

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Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition

Cited by 13 publications

References 56 publications

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

<p>IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma</p>

Role of TRIM16 in cancers development

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