Hypozincaemia in febrile convulsion

Burhanoğlu, Mengü; Tütüncüoğlu, Sarenur; Çöker, Canan; Tekgül, Hasan; Özgür, T.

doi:10.1007/bf01955189

Cited by 42 publications

(56 citation statements)

References 10 publications

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“…Mahyar et al and few other researchers have also reported similar findings in their studies suggesting that no specific age group or gender is particularly predisposed to develop hypozincemia. [16][17][18][19][20] A significant difference of 10.46 µg/dl in the mean serum zinc levels in cases(lower) compared to controls was also noted in the present study. The findings are consistent with some previous studies.…”

Section: Discussionsupporting

confidence: 73%

“…The findings are consistent with some previous studies. 5,[9][10][11][12][13]19,20 Hypozincemia in present study was found to be more prevalent in children with simple febrile seizures compared to the control group. However, no classical clinical manifestations of hypozincemia like diarrhoea, impaired appetite, decreased growth velocity, acroorificial skin lesions, delayed wound healing, dysguesia and hypoguesia were present in these patients, demonstrating purely biochemical hypozincemia.…”

Section: Discussionmentioning

confidence: 70%

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Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Hubaira¹,

Wani²,

Qadri³

2017

Int J Contemp Pediatr

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Background: Owing to the excessive susceptibility of the immature brain to temperature, febrile seizures remain one of the common neurological conditions of childhood. Although simple febrile seizures do not pose any increased neurological problems in adult life, but the anxiety, hospitalization and prophylaxis for the episode do call for a genuine concern. A correlation between zinc deficiency and febrile seizures has been proposed and a few studies undertaken have shown mixed conclusions. This case control study was undertaken to compare the serum Zinc levels in patients with simple febrile seizures against the controlled patients with short febrile illness without seizures and to find the correlation if any between simple febrile seizures and serum zinc levels.Methods: The hospital based, observational case control study was done in Batra Hospital and Medical research Centre, New Delhi. A total of 200 children aged 6 months to 6 years admitted in the hospital with history of short pyrexia (fever for 2 days or less) and fulfilling our inclusion criteria were enrolled for the study after taking an informed consent from their attendants and classified into 2 groups of 100 each as cases and controls. Patients with history of simple febrile seizures as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. The data was analysed on SPSS 17.Results: Our results showed a mean of serum zinc levels in cases as 61.53±15.87 mcg/dl which was found to be lower compared to controls as 71.90+18.50 mcg /dl. Further the difference was found to be statistically significant (P<0.05).Conclusions: Low serum zinc levels in the patients of simple febrile seizures in association with other risk factors may enhance the occurrence of seizures triggered by fever. Thus, a possible correlation exists between the mean serum zinc level and simple febrile seizures.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 70%

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Hubaira¹,

Wani²,

Qadri³

2017

Int J Contemp Pediatr

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“…However, FS represents the point between a low seizure threshold and genetic components, recognized to be susceptible for FS and caused by mutations in several gene maps, such as FEB-1 to FEB-4 (5-7). Moreover, some mutations causing neural hyperexcitability could be responsible for FS especially with polygenic multifactorial genetic trait (5,6,8).…”

mentioning

confidence: 99%

Major and minor bio-element status in children with febrile seizure

Akbayram¹,

Cemek²,

Büyükben³

et al. 2012

BLL

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Febrile seizures (FS) are the most common cause of seizures in children. The exact etiopathogenesis is unknown but involves factors like genetic predisposition and alterations in the levels of neurotransmitters and some trace elements. The study includes 48 consecutive children with FS, and 55 healthy age matched control subjects. Calcium, magnesium and potassium concentrations in the febrile study group were lower than in the control group (p<0.05). Iron and Gallium levels in the study group were lower than in the control group (p<0.01). Serum Selenium (p<0.001), Zinc (p<0.001) and Strontium (p<0.05) levels were signifi cantly decreased in the study group when compared to the control group. There was no signifi cant difference between the control and study groups in Serum Barium, Beryllium and Copper levels (p>0.05). The aim of the present prospective analytical case-control study was to determine whether there was any change in element levels in children with FS (Ref. 33). Full Text in PDF www.elis.sk.

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“…In the case group, zinc levels were found to be significantly lower than those in other groups. Further, in other studies, mean serum zinc levels were found to be lower in patients with FC (27,28). Salehiomran and Mahzari (29) reported that the mean serum zinc level was 0.585±0.166 mg/L and 0.704±0.179 mg/L in the case and control groups, respectively.…”

Section: Casementioning

confidence: 77%

Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency

Gencer¹,

Kafadar²,

Köse³

et al. 2016

JAREM

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Objective: Febrile convulsion (FC) is the most common type of seizure in children. Its incidence is 2-5%. Iron and zinc, as a major element of some enzymes, play an important role in the central nervous system (CNS) and can affect some inhibitory mechanisms of CNS. The aim of this study is to evaluate the association of FC with iron deficiency anemia and zinc deficiency and the relationship of FC with its pathogenesis. Methods:We prospectively evaluated the demographic and clinical characteristics of FC in 57 children aged 3-60 months who presented to the pediatric emergency department as the case group and 25 healthy children who presented to outpatient clinics as the control group in Şişli Hamidiye Etfal Training and Research Hospital, a tertiary state hospital in İstanbul, between January 2013 and July 2013. Anemia was defined as a hemoglobin (Hb) level of <11 g/dL. The serum zinc levels were determined by atomic absorption spectrophotometry.Results: The male to female ratio was 1.71/1. The mean age at the first seizure was 21.6±11.8 months. The most common cause of FC was upper respiratory tract infection (84.2%). Twenty (35.1%) patients had a family history of FC and 8 (14%) had a family history of epilepsy. The most common seizure type was generalized tonic-clonic seizures (78.9%). There was no statistically significant difference between the case and control groups in the anemia ratio, Hb level, Htc, MCV, RDW, RBC count, platelet count, TIBC, and ferritin level. There were statistically significant lower rates of mean serum zinc levels and hypozincemia in the case group.Conclusion: There was no statistically difference between FC and anemia. The serum zinc levels were found to be lower in patients with FC. The relationship between low zinc levels and convulsion is not understood whether it is a cause or result. It can emphasize the hypothesis that there is a relation between serum zinc levels and febrile convulsion in children. (JAREM 2016; 6: 94-7)

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Hypozincaemia in febrile convulsion

Abstract: Serum and CSF Zn levels are decreased in children with febrile seizures. Zinc deprivation may play a role in the pathogenesis of febrile seizures.

Cited by 42 publications

References 10 publications

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Major and minor bio-element status in children with febrile seizure

Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency

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