Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

Jiang, Qiong; Zhou, Wei; Wang, Jun; Tang, Rupei; Zhang, Di; Wang, Xin

doi:10.1016/j.ijbiomac.2016.05.077

Cited by 79 publications

(23 citation statements)

References 43 publications

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“…Moreover, the 1‐(3‐dimethylaminopropyl)‐3‐ethylcarbodiimide hydrochloride (EDC)/ N ‐hydroxysuccinimide (NHS) catalyst system can be generally used to crosslink chitosan with other agents containing carboxyl groups. Jiang et al . produced hypromellose succinate (HPMCS) and then linked chitosan with HPMCS through amide bonds using EDC/NHS as a catalyst.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Introductionmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…Hydrogels are one of the most commonly used and tunable substrate materials that combine water absorption, retention, and controlled‐release abilities, which can be engineered into almost any shape and size. They are widely used in biosensors, wound dressings and drug release at the macro‐level . At the micro‐level, there is extensive use of hydrogels for mechanical stimulation to study cell‐ECM interactions .…”

Section: Introductionmentioning

confidence: 99%

“…They are widely used in biosensors, 26,27 wound dressings and drug release at the macro-level. [28][29][30][31] At the micro-level, there is extensive use of hydrogels for mechanical stimulation to study cell-ECM interactions. 20,32,33 Recently, diverse techniques have been utilized for systematic study of the effects of gradient stiffness substrates on cell behaviors including physical crosslinking, photopolymerization and microengineering structuralization technologies.…”

Section: Introductionmentioning

confidence: 99%

A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine

Xia

Liu

Yang

2017

J Biomedical Materials Res

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Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale. Basic and clinical applications for gradient stiffness hydrogels in tissue engineering and regenerative medicine continue to drive the development of stiffness and structure varied hydrogels. Given the importance of gradient stiffness hydrogels in basic research and biomedical applications, there is a clear need for systems for gradient stiffness hydrogel design strategies and their applications. This review will highlight past work in the field of gradient stiffness hydrogels fabrication methods, mechanical property test, applications as well as areas for future study. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1799-1812, 2017.

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“…of hydrogels prepared by chemical cross-linking is relatively stable. The physical properties of hydrogel are similar to the properties of living tissues, such as high water content, rubbery texture, and low interfacial tension, which contribute to its outstanding biocompatibility with the surrounding tissues [6]. The mechanical property, shape, and swelling performance of some hydrogels tend to change with the external conditions, such as temperature, pH value, and ion concentration [7][8][9].…”

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confidence: 99%

An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors

Tang

Zhao

2019

Polymers

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To fabricate environmentally sensitive hydrogels with better biocompatibility, natural materials such as protein and polysaccharide have been widely used. Environmentally sensitive hydrogels can be used as a drug carrier for sustained drug release due to its stimulus responsive performance. The relationship between the internal structure of hydrogels and their drug delivery behaviors remains indeterminate. In this study, environmentally sensitive hydrogels fabricated by blending silk fibroin/chitosan with different mass ratios were successfully prepared using 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (EDC)/N-Hydroxysuccinimide (NHS) cross-linking agent. Scanning-electron microscopy (SEM) images showed the microcosmic surface of the gel had a 3-D network-like and interconnected pore structure. The N 2 adsorption-desorption method disclosed the existence of macroporous and mesoporous structures in the internal structure of hydrogels. Data of compression tests showed its good mechanical performance. The swelling performance of hydrogels exhibited stimuli responsiveness at different pH and ion concentration. With the increase of pH and ion concentration, the swelling ratios of hydrogels (silk fibroin (SF)/ chitosan (CS) = 8/2 and 7/3) decreased. Methylene blue (MB) was loaded into the hydrogels to confirm the potential of sustained drug release and pH-responsive behavior. Therefore, due to the porous structure, stable mechanical strength, stimuli responsive swelling performance, and drug release behaviors, the SF/CS composite hydrogels have potential applications in controlled drug release. of hydrogels prepared by chemical cross-linking is relatively stable. The physical properties of hydrogel are similar to the properties of living tissues, such as high water content, rubbery texture, and low interfacial tension, which contribute to its outstanding biocompatibility with the surrounding tissues [6]. The mechanical property, shape, and swelling performance of some hydrogels tend to change with the external conditions, such as temperature, pH value, and ion concentration [7][8][9]. Drugs can be delivered through hydrogels with stimuli responsiveness to pH, magnetism, ultrasound, temperature changes, and electrical effects [8]. The stimuli responsiveness of hydrogel makes it potential material for drug release, which has been proved in previous studies [10][11][12]. Cross-linking mechanism or pore structure of hydrogels may be the cause of stimuli responsiveness, which has not been revealed. In this study, a pH-and ion intensity stimuli-responsive silk fibroin/chitosan hydrogel was prepared by chemical cross-linking. The mechanism of stimulus responsiveness of the hydrogel was also indicated.Silk fibroin (SF) is a kind of natural material with high molecular weight, good biocompatibility, and mechanical strength [13]. Hydrogel made of silk fibroin has broad application prospects in artificial skin, wound dressing, sustained drug release, tissue engineering scaffolds, and so on [14-17]. Chitosan (CS) is a natural ba...

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Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing

Cited by 79 publications

References 43 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine

An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors

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