Hyptis verticillata attenuates dyslipidaemia, oxidative stress and hepato-renal damage in streptozotocin-induced diabetic rats

Background and purpose: Erynginum billardieri has been used to control diabetes in traditional medicine. This research was performed to study the antidiabetic, hepatoprotective, and hypolipidemic effects of E. billardieri root extract (EBRE) on streptozotocin/nicotinamide-induced type 2 diabetic male rats. Experimental approach: Type two diabetic animals were treated by three different doses of EBRE (100, 200, and 400 mg/kg), orally administered for 4 weeks. Ultimately, after anesthesia, the glucose, insulin, lipid profiles, hepatic enzyme levels in the blood and liver, and pancreas tissues of the animals were analyzed. Findings/Results: Induction of diabetes caused a diminution in insulin level, high-density lipoprotein (HDL), and significantly enhanced the level of other lipid profiles, glucose, and liver enzymes ( P < 0.05). Administration of the EBRE to diabetic-male rats significantly reduced glucose level, lipid profiles, and liver enzymes, and increased the level of HDL to near normal. Conclusion and implications: The results of the present study showed that E. billardieri had a positive effect on diminishing the lipid profiles, liver enzymes, and controlling diabetes. The most effective dose was found to be 100 mg/kg.

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“…One of the important insulin-dependent tissues is the liver, which is damaged during type II diabetes mellitus ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Khani

Abdollahi

Asadi

et al. 2021

Research in Pharmaceutical Sciences

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“…36 SOD is one of the main enzymes that could convert superoxide radical to hydrogen peroxide, 37,38 and GPx and CAT are both key enzymes that believed to have the principal roles in detoxifying hydrogen peroxide to water and oxygen. [39][40][41] Hydrogen peroxide and hydrogen peroxide are known oxygen free radicals that oxidize GSH to GSSG, 38,42,43 thus increasing the enzymatic activities of GST, GPx, SOD, and CAT could benefit the elevation of hepatic GSH. In the current study, IF significantly restored APAP-induced reduction of the GSH in mice liver, which further confirmed that hepatic GSH-related enzymes were involved in the protective actions of IF against APAP-induced hepatic oxidative injury (shown in Figure 5).…”

Section: Discussionmentioning

confidence: 99%

“…GPx, SOD, and CAT are important enzymes that could promote the conversion of GSSG to GSH 36 . SOD is one of the main enzymes that could convert superoxide radical to hydrogen peroxide, 37,38 and GPx and CAT are both key enzymes that believed to have the principal roles in detoxifying hydrogen peroxide to water and oxygen 39‐41 . Hydrogen peroxide and hydrogen peroxide are known oxygen free radicals that oxidize GSH to GSSG, 38,42,43 thus increasing the enzymatic activities of GST, GPx, SOD, and CAT could benefit the elevation of hepatic GSH.…”

Section: Discussionmentioning

confidence: 99%

Isatidis Folium alleviates acetaminophen‐induced liver injury in mice by enhancing the endogenous antioxidant system

Ding

Zhu

2020

Environmental Toxicology

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Isatidis Folium (IF) has been clinically combined with acetaminophen (APAP), but the rationality of combinational therapy is still ambiguous. In the present study, the protective effect and related mechanism of IF on APAP-induced hepatotoxicity were evaluated. Hepatic histopathology and blood biochemistry investigations clearly demonstrated that IF could restore APAP-induced hepatotoxicity. Liver distribution study indicated that the hepatoprotective effect of IF on APAP is attributed to the reduction of N-acetyl-p-benzoquinone imine (NAPQI) in liver, which is a known hepatotoxic metabolite of APAP. Further study suggested the reduction is not via decreasing the generation of NAPQI through inhibiting the enzyme activities of CYP 1A2, 2E1, and 3A4 but via accelerating the transformation of NAPQI to NAPQI-GSH by promoting GSH and decreasing GSSG contents in liver. Furthermore, IF significantly enhanced the hepatic activities of GSH-associated enzymes in APAP-treated mice. In summary, IF could alleviate APAP-induced hepatotoxicity by reducing the content of NAPQI via enhancing the level of GSH and the followed generation of NAPQI-GSH which might be ascribed to the upregulation of GSH-associated enzymes.

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“…The cardioprotective index (CI) has been studied in diabetic rats after treatment with quercetin for 28 days. Ogar et al [23] attributed the enhanced CI to the use of quercetin. The cardioprotective effects of quercetin, along with a dietary supplement, alpha-linolenic acid, have been described by Burak et al [24].The quercetin derivative was used to study cardiac dysfunction, scavenging free radicals, and reduced lipid peroxidation, as reported by Shu et al [25] and attributed cardioprotective effects of quercetin derivative to partially counteracted PI3K/Akt inhibitor LY294002.…”

Section: Quercetin As a Cardioprotective Agentmentioning

confidence: 99%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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Hyptis verticillata attenuates dyslipidaemia, oxidative stress and hepato-renal damage in streptozotocin-induced diabetic rats

Cited by 23 publications

References 38 publications

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Isatidis Folium alleviates acetaminophen‐induced liver injury in mice by enhancing the endogenous antioxidant system

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

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